Publications by authors named "Ishima M"
Article Synopsis
- Hypoxic zones in tumors make them resistant to radiation therapy, but drugs that improve oxygen levels, like SQAP, can enhance treatment effectiveness.
- The study used various imaging techniques to show how SQAP affects oxygen levels and blood flow in tumors before radiation.
- Results indicated that SQAP improves tumor oxygenation and blood perfusion, leading to better responses to radiation therapy and potentially delaying tumor growth.
Article Synopsis
- SQAP is a new strong radiosensitizer that helps inhibit blood vessel formation in tumors, leading to better oxygen levels and smaller tumor sizes.
- In a study with mice that had human lung cancer, researchers tracked how SQAP was distributed, broken down, and expelled from the body after injection.
- Results showed that while SQAP spread quickly throughout the body and decreased rapidly, it remained longer in tumor tissues compared to other organs, although radioactivity from SQAP disappeared entirely by 72 hours.
A Trial of Nursing Cost Accounting using Nursing Practice Data on a Hospital Information System.
Stud Health Technol Inform
April 2016
Hospital administration is very important and many hospitals carry out activity-based costing under comprehensive medicine. However, nursing cost is unclear, because nursing practice is expanding both quantitatively and qualitatively and it is difficult to grasp all nursing practices, and nursing cost is calculated in many cases comprehensively. On the other hand, a nursing information system (NIS) is implemented in many hospitals in Japan and we are beginning to get nursing practical data.
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- - The study describes the first successful total synthesis of MA026, a unique lipocyclodepsipeptide found in Pseudomonas sp. RtIB026, and identifies its potential target protein for combating hepatitis C virus (HCV).
- - MA026 is composed of a cyclodepsipeptide, chain peptide, and N-terminal (R)-3-hydroxydecanoic acid, with its synthesis involving intricate steps like calorie coupling and macrocyclization to create its active form.
- - Testing in HCV cell cultures shows that MA026 effectively reduces HCV infection by interfering with the virus's entry into liver cells, and further analysis identified claudin-1 as its specific target.
Although the MHC class II 'u' haplotype is strongly associated with type 1 diabetes (T1D) in rats, the role of MHC class II in the development of tissue-specific autoimmune diseases including T1D and autoimmune thyroiditis remains unclear. To clarify this, we produced a congenic strain carrying MHC class II 'a' and 'u' haplotypes on the Komeda diabetes-prone (KDP) genetic background. The u/u homozygous animals developed T1D similar to the original KDP rat; a/u heterozygous animals did develop T1D but with delayed onset and low frequency.
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- The study aimed to investigate how a specific lipid (α-SQMG) combined with X-irradiation affects tumor microenvironments in colon cancer cells.
- Using a human colon cancer cell line in mice, researchers monitored tumor growth and analyzed changes in microenvironment characteristics related to blood vessel formation and oxygen levels.
- Results showed that the combination treatment improved the effectiveness of radiation therapy, leading to significant changes in tumor vessels and their structures, potentially enhancing the response to further radiation.
This longitudinal study examined whether bone mineral density (BMD) of the lumbar spine and proximal femur is maintained in premenopausal caddies (n = 6; mean age 37.8 years) in comparison with desk workers (n = 6; mean age 40.8 years) at the same golf club.
View Article and Find Full Text PDFThe effect of hyaluronan (hyaluronic acid; HA) on the healing of rabbit meniscus injured in the peripheral region was assessed. A longitudinal tear was created in the peripheral region of the medial meniscus in 20 mature New Zealand white rabbits. One week after surgery, HA was injected into the left knee joint once a week for 5 weeks (HA group), while saline was injected into the right knee (control group).
View Article and Find Full Text PDFWe studied the effects of hyaluronan (HA) on chondrogenesis in periosteal grafts in rabbit knees to elucidate the effects of this agent in the repair of articular cartilage. Large full-thickness defects of the articular cartilage were created in the anteromedial part of the femoral articular surface of bilateral knee joints. Periosteal grafts were then harvested and sutured onto the defects.
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