Publications by authors named "Ishfaq Mohiuddin"
Ocular drugs have low absorption because of the unique environment in the eye, making ocular drugs one of the most challenging pharmaceutical initiatives. Liposomes have shown to be a promising ocular drug delivery system over the years because of enhanced drug absorption, biocompatibility, and biodegradability. Utilising a mucoadhesive material alongside liposomes could be a promising strategy to increase the therapeutic efficacy of ocular drugs.
View Article and Find Full Text PDFArticle Synopsis
- Cyclophosphamide (CYL) is a commonly used cancer chemotherapy drug that can lead to severe memory impairment due to its toxic effects from free radical generation.
- A study explored the protective effects of noni fruit juice (NJ), known for its antioxidant properties, against memory issues caused by CYL in Swiss albino mice.
- Results showed that while CYL treatment caused short-term memory impairment, combining NJ with CYL significantly improved memory and biochemical markers associated with oxidative stress and neuroprotection in the mice.
Article Synopsis
- Morinda citrifolia (noni) juice demonstrates potential antioxidant properties and may help prevent cancer by blocking carcinogen-DNA adduct formation.
- The study tested both in vitro (breast cancer cells) and in vivo (mice) to evaluate the anti-tumor effects of noni and its interaction with the chemotherapy drug cyclophosphamide (CYL).
- Results showed that noni improves the cytotoxic effects of CYL, enhances overall tumor inhibition, and alleviates adverse effects on blood parameters and biochemical markers associated with CYL treatment.
Background: Multidrug-resistant bacterial strains cause several serious infections that can be fatal, such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae (often referred to as ESKAPE pathogens). Since ancient times, several indigenous medical systems in India have utilized diverse medicinal plants (approximately 80,000 species) as conventional treatments for a variety of illnesses. A member of the Fabaceae family, also referred to as "Himalayan indigo," Indigofera heterantha Wall, is well known for its therapeutic properties.
View Article and Find Full Text PDF