Publications by authors named "Ishfaq Ahmad Baba"
Tuberculous meningitis, a severe complication of Mycobacterium tuberculosis (M. tb) infection, involves the dissemination of bacilli in the brain. This study explored the role of the sonic hedgehog (SHH) signaling pathway in regulating blood-brain barrier (BBB) integrity, M.
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- The rise in global antimicrobial resistance highlights the urgent need for new antibiotics, prompting researchers to explore innovative sources for bioactive compounds.
- Actinomycetes are a key focus due to their ability to produce a wide range of antimicrobial agents effective against various diseases, including tuberculosis and cancer.
- Recent advancements in synthetic biology and techniques like bioinformatics have renewed interest in marine actinomycetes, which remain largely untapped, offering potential for discovering next-generation antimicrobial drugs.
Article Synopsis
- The COVID-19 pandemic has led to a resurgence of Tuberculosis (TB), particularly with an increase in dangerous forms like Tuberculous Meningitis (TBM), due to disruptions in treatment programs like DOTS.
- TBM, although less common, presents higher mortality and morbidity rates compared to pulmonary TB, indicating a need for more focused research and awareness.
- The literature highlights critical areas for further investigation, including improved diagnostics, innovative treatments, the impact of the blood-brain barrier, and the relationship between TBM and COVID-19, aiming to enhance understanding and strategies against this serious illness.