The Strength of Rail Vehicles Transported by a Ferry Considering the Influence of Sea Waves on Its Hull.

The article presents the results of a determination of the load attributed to rail vehicles transported by a ferry, considering the influence of sea waves on its hull. A mathematic model describing the displacements of a train ferry, which transported rail vehicles on its decks during rolling oscillations, was created. Calculated accelerations were used to identify the load of components from a dynamics point of view and they were subsequently applied as an input to the analysis of the strength of the open wagon main-bearing structure in a standard scheme of interaction with a train ferry deck.

[Physical therapy in the rehabilitation of patients after endoprosthetic replacement of major joints in the lower extremities: a scientometric analysis of evidence-based studies].

Background: In recent decades, the volume of high-tech medical care in the field of orthopedics and traumatology, including endoprosthetic replacement of major joints (MJs) (the hip joint and/or the knee joint) in the lower extremities (LE) (LEMJ), has substantially increased. In this connection, there are an increasing number of patients in need of medical rehabilitation, to solve the problems of which needs the effective physical and rehabilitation medicine (PRM) techniques proven during researches to be introduced into practice.

Objective: To analyze evidence-based studies containing sound data on the use of PRM technologies in the rehabilitation of patients after endoprosthetic replacement of LEMJs, to identify the most effective PRM technologies and to formulate recommendations for their use for practitioners, which are based on the evidence obtained during the analysis.

[Age features of hemostatic system in people with insulin resistance and pre-diabetes carbohydrate metabolism disorders].

In pre-diabetes disorders in which pathogenesis the insulin resistance (IR) plays a leading role, the risk of thrombosis due to increased coagulation factors, decreased concentration of physiological anticoagulants and inhibition of fibrinolysis is increased. Similar changes in the hemostatic system with aging are observed. We investigated the characteristics of the hemostatic system in middle-aged and elderly people with IR in the absence and presence of impaired glucose tolerance (IGT).

[Hematopoietic stem cells and immune status of subjects with different hypoxic tolerance].

Intermittent hypoxia treatment (IHT) is gaining attention as a clinical modality due to its capacity to protect cells, tissues, organs, and the whole organism from more intense and/or sustained hypoxia, ischemia and other stresses, to enhance physical and mental capacity. Circulating hematopoietic stem and progenitor cells (HSPC) play an important role in immune response to hypoxia ensuring tissue reparation processes, formation of all types of blood cells etc. There exist considerable individual differences in the capability to mobilize HSPC.

Intermittent hypoxia mobilizes hematopoietic progenitors and augments cellular and humoral elements of innate immunity in adult men.

This study tested the hypothesis that intermittent hypoxia treatment (IHT) modulates circulating hematopoietic stem and progenitor cells (HSPC) and augments humoral and cellular components of innate immunity in young, healthy men. Ten subjects (group 1: age 31±4 yr) were studied before and at 1 and 7 days after a 14-day IHT program consisting of four 5-min bouts/day of breathing 10% O2, lowering arterial O2 saturation to 84% to 85%, with intervening 5-min room-air exposures. Five more subjects (group 2: age 29±5 yr) were studied during 1 IHT session.

[Insulin resistance and physical performance in middle age and elderly people].

In 43 middle age and elderly people without obesity (body mass index of less than 30 kg/m2) we studied the relationship between insulin resistance (IR) and physical performance. It is shown that in healthy elderly IR is associated with a moderate increase of insulin and a small increase in the level of glucose in the blood plasma. In the middle age people, IR has no effect on physical performance.

[Effectiveness of intermittent normabaric hypoxic trainings in elderly patients with coronary artery disease].

The intermittent normabaric hypoxic training (IHT) is a non-pharmacological method, which due to several positive effects, has been used successfully in treating patients with cardiovascular diseases (CVD). However, the application of this method in the elderly has its own peculiarities because of age-related changes of organism. The article presents the indications and limitations of IHT in elderly people with coronary artery disease, the method of the mode of training in the elderly, as well as displaying the results of our clinical study of the safety and efficacy of IHT in 45 elderly patients with stable angina of I and II functional classes.

[Individual characteristics of human adaptation to intermittent hypoxia: possible role of genetic mechanisms].

The majority of the adaptation processes to hypoxia is based on transcriptional regulation by hypoxia-inducible factors--HIFs. Recently the allele polymorphism of oxygen-dependent degradation domain of HIF-lalpha has been described. It consists in the replacement of cytosine for thymine in 1772 location (C1772-->T).

[Physiological adaptation reactions in patients with ischemic heart disease].

The condition was studied of bodily general adaptive reactions in patients with different forms of ischemic heart disease (IHD). Unlike healthy subjects, IHD patients displayed predominance of pathogenetic and dysadaptive type reactions. 88 percent of healthy subjects had reactions of sanogenetic character, with 31.

[Application of carboxyline in prophylaxis of subclinical ketoses in lactating cows].

The feeding of carboxyline to lactating cows, their maintenance in rations balanced for the sugar-protein proportion and organization of the active exercises favour normalization of metabolism with subclinical ketoses. This is accompanied by a decrease in the content of ketonic bodies in blood, milk and urine with a simultaneous increase in the amount of citric acid. The content of sugar and alkaline reserves in blood increases, the amount of pyruvic acid decreases.