Host- and pathogen-derived adjuvant coatings on protein nanoparticle vaccines.

Nanoparticulate and molecular adjuvants have shown great efficacy in enhancing immune responses, and the immunogenic vaccines of the future will most likely contain both. To investigate the immunostimulatory effects of molecular adjuvants on nanoparticle vaccines, we have designed ovalbumin (OVA) protein nanoparticles coated with two different adjuvants-flagellin (FliC) and immunoglobulin M (IgM). These proteins, derived from and mice, respectively, are representatives of pathogen- and host-derived molecules that can enhance immune responses.