Publications by authors named "Ishaq Nasib Khan"

Article Synopsis
  • The study isolated five fungal endophytes from the roots and stems of a specific plant and tested their culture filtrates against glioblastoma cells (U-87), showing promising anti-tumor activity.
  • The fungal culture filtrates exhibited varying levels of potency, with the most effective having an IC50 value of 0.95 µg/mL.
  • Notably, HPLC analysis of one endophyte (WS-6) revealed 11 compounds with significant anti-tumor effects, with new compounds identified that could contribute to future drug development for brain tumors.
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Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus which is endemic to certain regions of the world and infects around 10-20 million people. HTLV-1 is the etiologic agent of Adult T cell leukemia/lymphoma and HTLV-1 associated neurological disorders including mainly HTLV-1 associated myelopathy/Tropical spastic paraparesis. The involvement of the central nervous diseases occurs among: HTLV-1 infected patients from endemic areas, HIV positive individuals and drug users.

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Injuries to the spinal cord often have devastating physiological impacts due to the organ's vital role in neuro-impulse communications between muscles and the brain. Spinal Cord Injuries (SCIs) have recently been estimated to affect up to 80,000 individuals per year worldwide, with most occurring following a traumatic event. Unfortunately, effective treatments standardised globally for patients with SCIs have not yet been established.

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