Publications by authors named "Ishan Khosla"
Study Design: Retrospective review.
Objective: To evaluate how preoperative disability influences patient-reported outcomes (PROs) following primary surgical intervention for cervical herniated disc.
Summary Of Background Data: The effect of baseline disability has been evaluated for various spinal surgeries, but not specifically for primary cervical herniated disc.
Background: Prior literature has examined predictors of length of stay (LOS) for lumbar fusion broadly, grouping multiple surgical approaches into one sample. Evaluating minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) specifically can reduce variability introduced by other approaches to effectively identify predictors of LOS. The purpose of this study is to evaluate preoperative predictors of extended LOS in patients undergoing MIS-TLIF.
View Article and Find Full Text PDFStudy Design: Retrospective review.
Objective: To evaluate mental health influence on minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) patients.
Summary Of Background Data: Poor mental health has been postulated to indicate inferior patient perceptions of surgical outcomes in spine literature.
Article Synopsis
- This study focuses on how preoperative motor weakness (MW) influences Patient-Reported Outcome Measures (PROMs) in patients undergoing lateral lumbar interbody fusion (LLIF).
- It includes data from 214 patients, with 149 experiencing MW, and analyzes various outcomes like physical function, pain levels, and quality of life before and after surgery.
- The findings indicate that while there were some demographic and perioperative differences between patients with and without MW, MW did not have a significant impact on overall PROM outcomes or minimum clinically important differences, except for one measure related to disability scores.
Introduction: Patients with a prolonged preoperative symptom duration (PSD) in the setting of cervical disk herniation (DH) may suffer inferior outcomes after surgical intervention. Comparison between anterior cervical diskectomy and fusion (ACDF) versus cervical disk arthroplasty (CDA) in this at-risk population has not yet been conducted.
Methods: Patients undergoing ACDF or CDA for DH with a PSD > 180 days were selected.
Article Synopsis
- Little research has explored how short-term postoperative patient-reported outcomes (PROs) predict long-term outcomes after lumbar decompression (LD), prompting a study to evaluate this relationship over two years.
- The study analyzed data from 277 patients, focusing on various PRO measures, such as pain scales and disability indexes, assessed at multiple time points, including 6 weeks, 6 months, 1 year, and 2 years post-surgery.
- Findings showed that 6-week PROs are strong predictors for outcomes at 6 months, with certain measures remaining predictive through 1 or even 2 years, aiding in understanding patient recovery trajectories and setting expectations.
The influence of Charlson Comorbidity Index (CCI) burden on Patient-Reported Outcomes Measurement Information System (PROMIS) outcomes following lumbar decompression (LD) is limited. The objective of this study is to evaluate CCI burden impact on PROMIS outcomes. Retrospective review of elective LD excluding revision or surgeries for infectious, malignant, or traumatic reasons.
View Article and Find Full Text PDFObjective: To evaluate preoperative disability's influence on patient-reported outcomes (PROs) following surgery for degenerative spondylolisthesis (DS).
Methods: DS patients who underwent surgical intervention were retrospectively identified from a single-surgeon spine registry. Cohorts based on Oswestry Disability Index (ODI) < 41 (milder disability) and ≥ 41 (severe disability) were created.
Objective: To evaluate the effect of Veterans RAND 12-item health survey mental composite score (VR-12 MCS) on postoperative patient-reported outcome measures (PROMs) after undergoing lateral lumbar interbody fusion.
Methods: Retrospective data from a single-surgeon database created 2 cohorts: patients with VR-12 MCS ≥ 50 or VR-12 MCS < 50. Preoperative, 6-week, and final follow-up (FF)- PROMs including VR-12 MCS/physical composite score (PCS), 12-item Short Form health survey (SF-12) MCS/PCS, Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF), Patient Health Questionnaire-9 (PHQ-9), visual analogue scale (VAS)-back/leg pain (VAS-BP/LP), and Oswestry Disability Index (ODI) were collected.
Article Synopsis
- The article talks about using antibiotics correctly during spine surgery to prevent infections and treat them.
- It suggests hospitals need to work together to choose the right antibiotics, how much to use, and how long to give them to help fight against antibiotic resistance.
- Lastly, the article encourages more research to find better ways to prevent and treat infections in spine surgery.
Objective: To determine prognostic value of preoperative Veterans RAND 12-Item Health Survey (VR-12) physical composite score (PCS) on outcomes in patients undergoing anterior cervical discectomy and fusion (ACDF).
Methods: ACDF patients with preoperative VR-12 PCS formed 2 cohorts: VR-12 PCS <35 and VR-12 PCS ≥35. The following patient-reported outcome measures (PROMs) were gathered preoperatively and postoperatively up to 2 years: VR-12 mental composite score (MCS)/PCS, Neck Disability Index (NDI), Patient-Reported Outcomes Measurement Information System (PROMIS) PF, 9-Item Patient Health Questionnaire (PHQ-9), visual analog scale (VAS) neck/arm pain, and 12-Item Short Form Health Survey (SF-12) PCS/MCS.
Homozygous mutations in the gene encoding the scavenger mRNA-decapping enzyme, DcpS, have been shown to underlie developmental delay and intellectual disability. Intellectual disability is associated with both abnormal neocortical development and mRNA metabolism. However, the role of DcpS and its scavenger decapping activity in neuronal development is unknown.
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