Publications by authors named "Ishai Heusler"
Article Synopsis
- Galactin-3 is involved in crucial reproductive processes like oocyte maturation and implantation, and its expression may predict successful embryo implantation during IVF.
- A study involving 21 women undergoing IVF measured Galactin-3 levels in blood and follicular fluid at various stages of the IVF cycle.
- Results showed that higher Galactin-3 levels on the trigger day were associated with successful pregnancies, suggesting its role in fertility and the impact of inflammation on IVF success.
Inflammasome activation in preeclampsia and intrauterine growth restriction.
Am J Reprod Immunol
October 2022
Article Synopsis
- Preeclampsia (PE) and intrauterine growth restriction (IUGR) are common pregnancy complications linked to high rates of maternal and neonatal issues, potentially driven by inflammasome-related inflammation in the placenta.* -
- In a study involving women with PE, IUGR, and normal pregnancies, researchers found elevated levels of inflammasome proteins NLRP7 and PYCARD in placental tissues from those with complications compared to normal pregnancies.* -
- Elevated NLRP7 and PYCARD levels in PE and IUGR samples suggest these proteins could serve as important biomarkers for predicting and understanding the progression of these conditions.*
Objectives: Preeclampsia (PE) is a pregnancy-related syndrome characterized by the onset of hypertension and proteinuria that can lead to end-organ dysfunction. Galectin-3 (Gal-3) is involved in cell growth, differentiation, inflammation and fibrosis. Thioredoxin (TXN) acts as antioxidant enzyme in several cellular processes, regulating inflammation and inhibiting apoptosis.
View Article and Find Full Text PDFBackground And Aims: Gestational diabetes mellitus (GDM), hyperglycemia diagnosed during pregnancy, is one of the most common medical complications of pregnancy, treated primarily by diet and pharmacotherapy, if indicated. It is well-established that GDM increases the risk of adverse pregnancy outcomes and long-term complications in mothers and infants. Galectin-3 (Gal-3) is important in processes of cell growth, differentiation, inflammation, and fibrosis.
View Article and Find Full Text PDFPostpartum visits in the gynecological emergency room: How can we improve?
BMC Pregnancy Childbirth
May 2020
Background: The attendance to the gynecological-emergency-room (GER) of women only a few weeks following previous discharge after birth comprises a medical as well as social problem. The objective of the study was to characterize the postpartum women that attended the GER, and depict the leading etiologies and risk-factors that lead them to attend the GER, and to examine correlations between their medical findings at discharge and the reasons for their attendance to the hospital.
Methods: All women that attended the GER between 01/01/2016 and 30/09/2016 during 6 weeks after birth were included.
The temporal effect of Category II fetal monitoring on neonatal outcomes.
Eur J Obstet Gynecol Reprod Biol
October 2018
Objective: To correlate the duration of Category II cardiotocograms (CTG) with adverse neonatal outcomes associated with perinatal asphyxia and determine the duration before fetal compromise.
Study Design: This retrospective, observational study used electronic medical record data from a cohort of 271 patients, delivered by C-section due to non-reassuring fetal heart rate, at a tertiary medical center, from 2015 through 2017. Duration of Category II CTG, variability, tachycardia and deceleration frequency were analyzed and correlated to immediate postnatal outcomes.
Article Synopsis
- Left posterior fascicular ventricular tachycardia (LPF-VT) is often confused with supraventricular tachycardia, particularly when aberrancies like right bundle branch block (RBBB) and left anterior hemiblock (LAHB) are present.
- A study was conducted analyzing ECGs from patients with LPF-VT, RBBB, and LAHB, revealing distinct ECG features that can help differentiate between these conditions.
- A prediction model was created using specific ECG characteristics, demonstrating an accuracy of over 80% in correctly identifying LPF-VT, making it a useful tool for clinicians.