Publications by authors named "Isha Puntambekar"
Article Synopsis
- White matter changes in temporal lobe epilepsy (TLE) are linked to cognitive impairments and possible neurodegenerative processes, with a study examining surgical resections from 44 patients.
- The research found increased arteriolosclerosis and alterations in microvascular structure, including reduced vessel size and higher pericyte coverage, particularly in deeper white matter, independent of age and linked to epilepsy duration.
- Additionally, there were significant changes in glial and myelin cell densities, with gene expression analysis indicating stronger myelination reductions in patients with hippocampal sclerosis, highlighting a relationship between imaging abnormalities and cognitive decline.
Introduction: About 25 % of new-onset epilepsies are diagnosed after age 65. Late-onset epilepsy (LOE) is predicted to become a major healthcare problem in the next 15 years as the global population increases and ages. Neurodegenerative disorders account for 10-20 % of LOE, while over 20 % of these patients have an unknown etiology.
View Article and Find Full Text PDFNeuropsychological correlates of visual hallucinatory phenomena in Lewy body disease.
Int J Geriatr Psychiatry
June 2023
Objectives: Visual hallucinations (VH) ranging from minor to complex, are the most common psychiatric feature of Lewy Body Disease (LBD). Despite their high prevalence and poor prognostic implications instigating extensive research, the precise mechanisms underlying VH remain unclear. Cognitive impairment (CI) is a risk factor and a consistent correlate of VH in LBD.
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