Publications by authors named "Isha Pathak"
Stem Cell Res Ther
May 2021
Article Synopsis
- Mucopolysaccharidosis IVA (Morquio A syndrome) is caused by a deficiency of the GALNS enzyme, leading to harmful accumulations of GAGs in various tissues, and current enzyme replacement therapy (ERT) has limitations in treating all aspects of the disease.
- Researchers cultured human umbilical mesenchymal stem cells (UMSC) to analyze their ability to produce GALNS enzyme and to examine how extracellular vesicles (EVs) from these cells can be used by GALNS-deficient cells.
- The study found that EVs released by UMSC contained active GALNS and were successfully taken up by deficient fibroblast cells, suggesting an efficient mechanism for enzyme delivery not relying on traditional pathways, potentially improving treatment for Mor
