Publications by authors named "Isha Kohli"

Article Synopsis
  • Inflammatory bowel disease (IBD) significantly impacts patient health, with recent studies linking sarcopenia (muscle loss) to decreased quality of life and poor clinical outcomes.
  • An analysis of over 1.5 million hospitalizations showed that patients with sarcopenia had higher rates of in-hospital mortality (4.2% vs. 1.2%), ICU admissions, and required more surgeries compared to those without sarcopenia.
  • The study concludes that managing sarcopenia is essential for improving health outcomes in IBD patients, as it was associated with a nearly threefold increase in the risk of dying during hospitalization.
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Objective: The only curative treatment for patients with end-stage liver disease (ESLD) is liver transplantation (LT). Patients with ESLD can develop delirium due to multiple etiologies. In this study, we aimed to assess the prevalence and impact of delirium on outcomes and resource utilization among hospitalized patients undergoing LT.

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Background And Aims: Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory condition. Associated pathologies for EoE are similar to those with metabolic-dysfunction-associated steatotic liver disease (MASLD). This study assesses whether an association exists between MASLD and EoE.

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Cannabis, one of the most widely used recreational drug in the United States, has had a significant surge in usage following its legalization in 1996. In recent years, there has been research into the physiological effects of cannabis on the gastrointestinal (GI) system. Our study aims to systematically examine the association between cannabis use and complications of gastroesophageal reflux disease (GERD).

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Background And Aims: Previous studies have reported gender differences in patients with gastroesophageal reflux disease (GERD). These studies have also reported differences based on gender in the rates of complications. In this study, we aim to identify gender disparities in the rates of GERD complications in the United States.

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Background: Clostridioides difficile infection (CDI) is a significant cause of morbidity and mortality among hospitalized patients, particularly those who are immunosuppressed. We aim to assess the outcomes of CDI among kidney transplant (KT) recipients.

Methods: Nationwide Inpatient Sample from 2016 to 2020 was used to identify patients with KT and stratify based on the presence of CDI.

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Objectives: The study aimed to compare the risk of gastrointestinal infections among patients with and without metabolic dysfunction-associated fatty liver disease (MAFLD).

Methods: This was a population-based, retrospective, observational study using data from the National Inpatient Sample (NIS), the largest all-payer US inpatient care database.

Setting: Hospitalisation of adults aged ≥18 years old admitted in 2020 was identified using the NIS.

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Objectives: Aspiration pneumonia is a rare but feared complication among patients undergoing esophagogastroduodenoscopy (EGD). Our study aims to assess the incidence as well as risk factors for aspiration pneumonia in patients undergoing EGD.

Methods: National Inpatient Sample 2016-2020 was used to identify adult patients undergoing EGD.

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Background: Inflammatory bowel disease (IBD) is an inflammatory disorder that can increase the risk of mortality. Aspirin is an anti-inflammatory drug used for primary prevention of cardiovascular events. A single center analysis previously reported that aspirin use did not impact major outcomes in IBD.

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Background: Liver transplant recipients (LTR) and patients with chronic liver disease (CLD) are at an increased risk of infections.

Aims: The objective of our study was to assess the incidence, and impact of vaccine preventable illness (VPI) on outcomes in LTR.

Methods: National Inpatient Sample (NIS) 2016-2020 was used to identify adults (age > 18) hospitalized LTR using ICD-10 codes.

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Introduction Gastroparesis (GP) is a chronic debilitating gastric motility disorder defined as delayed emptying of the stomach content without mechanical obstruction. It can result in nutritional deficiencies, leading to poor overall outcomes. We assessed the impact of malnutrition on in-hospital outcomes in patients with gastroparesis.

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Article Synopsis
  • * A study analyzing data from the 2016-2020 National Inpatient Sample revealed that over half of the 98,160 patients with decompensated cirrhosis received PC consultations, with utilization rates increasing from 2016 to 2019 but slightly decreasing in 2020.
  • * The research found that receiving PC correlated with fewer invasive procedures and lower healthcare costs; however, minority groups and lower-income patients were less likely to access PC compared to their White counterparts and higher-income
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Background/aims: Celiac disease (CD) is a T-cell-mediated gluten sensitivity that results in villous atrophy in the small intestine, leading to chronic malabsorption. Patients with celiac disease are prone to malnutrition. We assessed the impact of malnutrition on in-hospital outcomes in patients with CD.

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Introduction  Acute pancreatitis (AP) is a common inflammatory disorder with acute onset and rapid progression. Studies have reported cardiac injury in patients with AP. It is often thought that stress cardiomyopathy can induce these changes leading to type 2 myocardial infarction (type 2 MI) in AP.

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This article reports the characterisation of pyrolysis of automotive shredder residue using in situ synchrotron IR, gas-phase IR, and thermal analyses to explore if the automotive shredder residue can be converted into value-added products. When heating to ~600 °C at different heating rates, thermal analyses suggested one- to two-stage pyrolysis. Transformations in the first stage, at lower temperatures, were attributed to the degradation of carbonyl, hydroxyl, or carboxyl functional stabilisers (aldehyde and ether impurities, additives, and stabilisers in the ASR).

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Article Synopsis
  • The study examines the impact of the COVID-19 pandemic on alcohol-related hepatitis (ARH) cases in the U.S., finding a significant rise in hospitalizations from 2019 to 2020.
  • Data from the National Inpatient Sample showed that ARH cases increased by 12.4% in 2020, with women experiencing a 14.2% rise and men a 12.2% rise compared to previous years.
  • Additionally, mortality rates for ARH patients also escalated sharply, with deaths increasing by 24.6% in 2020, indicating more severe cases during the pandemic.
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Article Synopsis
  • The study focuses on the impact of frailty in patients with liver disease undergoing transjugular intrahepatic portosystemic shunt (TIPS), revealing that frail patients experience worse post-procedural outcomes.
  • Using data from the National Inpatient Sample between 2016 and 2019, the researchers classified patients based on a Hospital Frailty Risk Score and found significant differences in mortality, hospital stay length, and overall costs between frail and non-frail patients.
  • The findings suggest that assessing frailty can enhance risk stratification and inform treatment decisions for patients undergoing TIPS procedures.
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Introduction: Although the effect of rectal indomethacin in post-endoscopic retrograde cholangiopancreatography pancreatitis is well established, the effect of aspirin on acute pancreatitis (AP) is not well studied. We investigate the effect of aspirin on AP.

Methods: We collected data from the National Inpatient Sample database from 2016 to 2020, to identify adult patients with acute pancreatitis.

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Background/objective: Portal vein thrombosis (PVT) is a well-known complication in patients with acute pancreatitis (AP). Limited data exist on the incidence and factors of PVT in patients with AP. We investigate the incidence and clinical predictors of PVT in AP.

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Synthetic dyes and colourants have been the mainstay of the pigment industry for decades. Researchers are eager to find a more environment friendly and non-toxic substitute because these synthetic dyes have a negative impact on the environment and people's health. Microbial pigments might be an alternative to synthetic pigments.

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Background: Although SARS-CoV-2 primarily affects the respiratory system, gastrointestinal symptoms were also seen. Our study analyzed the prevalence and impact of acute pancreatitis (AP) on COVID-19 hospitalizations in the United States.

Methods: The 2020 National Inpatient Sample database was used to identify patients with COVID-19.

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Background And Aim: Clostridioides difficile infection (CDI) is the leading cause of hospital acquired-infectious diarrhea in the USA. In this study, we assess the prevalence and impact of CDI in COVID-19 hospitalizations in the USA.

Methods: We used the 2020 National Inpatient Sample database to identify adult patients with COVID-19.

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Background: Acute pancreatitis (AP) carries a significant morbidity and mortality worldwide. AP is a potential complication of hematopoietic stem cell transplantation (HSCT) although its incidence remains unclear. HSCT recipients are at increased risk of AP due to various factors but the effect of AP on mortality and resource utilization in the adult population has not been studied.

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Introduction Multiple studies have shown that outcomes of various diseases differ by the hospital teaching status. However, not much is known about the effects of hospital teaching status on outcomes of acute pancreatitis (AP). The aim of this study was to identify if there was an effect of hospital teaching status on the outcomes of AP.

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