Publications by authors named "Isdin Oke"
Purpose: To evaluate the cost-utility of Luminopia and CureSight as therapy for amblyopia compared to current common amblyopic treatments such as glasses, atropine drops, and patching.
Design: Cost analysis based on data from published randomized control trials (RCTs).
Subjects: None; based on data from the Luminopia, CureSight and atropine RCTs.
This cross-sectional study used data from the American Academy of Ophthalmology IRIS Registry (Intelligent Research in Sight) and machine learning algorithms to identify pediatric ophthalmologists based on physician coding patterns. A random forest model achieved an area under the receiver operating characteristic curve of 0.98, sensitivity of 0.
View Article and Find Full Text PDFPurpose: To identify which features of Sturge-Weber syndrome (SWS) were most associated with glaucoma onset, severity, and treatment failure at a tertiary care center.
Design: Retrospective cross-sectional study.
Subjects: Children who had SWS with and without glaucoma.
Purpose: To describe the clinical characteristics and outcomes of children with posterior segment coloboma (PSC).
Methods: The medical records of children (age <18 years) with PSC examined at Boston Children's Hospital from May 1997 to May 2023 were reviewed retrospectively. The following data were collected: demographics, ocular and systemic conditions, coloboma type according to the Ida Mann (IM) classification, and best-corrected visual acuity.
Purpose: To describe the prevalence and risk factors associated with amblyogenic refractive error in children with Coats disease.
Methods: The medical records of children (<18 years of age) with unilateral Coats disease treated at a single tertiary care center were retrospectively reviewed. Data collected included patient demographics, ocular examinations, and treatments.
Article Synopsis
- The study investigates racial, ethnic, and sex disparities in enrollment for Pediatric Eye Disease Investigator Group (PEDIG) clinical studies, comparing the demographic data to the 2010 US Census for the pediatric population.
- It analyzes data from PEDIG studies conducted in the US between 1997 and 2022, focusing on race, ethnicity, and sex of participants using various sources including published studies and ClinicalTrials.gov.
- Results include statistical comparisons of enrollment percentages, identifying underrepresentation or overrepresentation of specific groups, and examining factors influencing these disparities.
Article Synopsis
- This study assessed how well three large language models (LLMs) - ChatGPT-3.5, ChatGPT-4, and Google Bard - could create and improve patient education materials (PEMs) for pediatric cataract.
- Researchers compared the responses from the LLMs based on prompts that varied in complexity and readability levels, specifically targeting sixth-grade understanding.
- Results showed that all LLMs produced high-quality and accurate materials, with ChatGPT-4 standing out for generating the most readable PEMs, effectively lowering the complexity to meet the specified reading level.
Purpose: To describe the prevalence of missing sociodemographic data in the IRIS® (Intelligent Research in Sight) Registry and to identify practice-level characteristics associated with missing sociodemographic data.
Design: Cross-sectional study.
Participants: All patients with clinical encounters at practices participating in the IRIS Registry prior to December 31, 2020.
Purpose: To describe the frequency of postoperative complications in children undergoing penetrating keratoplasty (PK).
Methods: This retrospective cohort study included pediatric patients (aged 0-18 years) in the Intelligent Research in Sight (IRIS) Registry who underwent primary PK between January 2013 and December 2020. Patients were identified using Current Procedure Terminology codes.
Article Synopsis
- The study aimed to analyze the clinical features, progression, and outcomes of uveitis in children diagnosed with tubulointerstitial nephritis and uveitis syndrome (TINU) through a multicentric retrospective cohort involving 110 patients.
- Findings showed that a significant majority (84%) of patients needed immunomodulatory treatment, with common initial therapies being methotrexate and mycophenolate mofetil, while about 45% required biologic agents for better control of uveitis.
- The results indicated that younger age, male sex, and higher severity of uveitis at diagnosis were linked to increased treatment needs, and by the end of the study, nephritis was managed in 90% of cases,
A healthy 4-year-old boy referred for evaluation of an abnormal red reflex in the left eye was noted, on fundus examination, to have extensive white, striated lesions surrounding the optic nerve that involved the superior and inferior macular arcades. On further examination, he was found to have ipsilateral high myopia and amblyopia. The triad of unilateral myelinated retinal nerve fibers, myopia, and amblyopia led to a diagnosis of Straatsma syndrome, which requires early treatment to prevent permanent vision loss.
View Article and Find Full Text PDFPurpose: To identify sociodemographic factors associated with the visual outcomes of retinoblastoma survivors.
Methods: Retrospective cohort study using a US-based clinical data registry. All individuals < 18 years of age with a history of retinoblastoma in the Intelligent Research in Sight (IRIS®) Registry (1/1/2013-12/31/2020).
Importance: Greater understanding of the association between strabismus and mental health conditions across sociodemographic backgrounds may inform strategies to improve mental well-being in this population.
Objective: To describe the association of strabismus with mental health conditions in a diverse cohort of US adults.
Design, Setting, And Participants: This cross-sectional study used data from the National Institutes of Health's All of Us Research Program, an ongoing program launched in 2015.
The Incidence of Strabismus After Upper and Lower Blepharoplasty in the United States.
Ophthalmic Plast Reconstr Surg
July 2024
Purpose: To compare the incidence of strabismus after upper and lower blepharoplasty in the United States.
Methods: Retrospective cohort study of adults (age ≥18 years) in the IRIS Registry (Intelligent Research in Sight) who underwent blepharoplasty between January 1, 2013 and December 31, 2020. The primary outcome was the Kaplan-Meier estimated cumulative incidence of strabismus diagnosis and surgery within 3 years of blepharoplasty.
This cross-sectional study used data from a large nationwide registry to describe the factors associated with use of botulinum toxin injections for adults with strabismus in the United States. Botulinum toxin injections were performed on 3.1% of adults undergoing an intervention for strabismus between 2013 and 2020.
View Article and Find Full Text PDFPurpose: To examine the relationship between the Child Opportunity Index (COI) and severity of retinoblastoma at presentation.
Design: Cross-sectional study.
Methods: Children (age <18 years) treated for retinoblastoma at a tertiary care center between January 2000 and May 2023 were included.
Importance: There is no consensus on the optimal surgical treatment for children with intermittent exotropia (IXT).
Objective: To compare the 5-year reoperation rates for children with IXT treated with horizontal muscle strabismus surgery using bilateral lateral rectus recession (BLR) vs unilateral lateral rectus recession with medial rectus resection (RR).
Design, Setting, And Participants: This cohort study examined data obtained from the Intelligent Research in Sight (IRIS) Registry on 7482 children (age, <18 years) with IXT who underwent horizontal eye muscle strabismus surgery between January 1, 2013, and December 31, 2017.