Publications by authors named "Isao Takemura"

There is an urgent need for new, potent antituberculosis (anti-TB) drugs with novel mechanisms of action that can be included in new regimens to shorten the treatment period for TB. After screening a library of carbostyrils, we optimized 3,4-dihydrocarbostyril derivatives and identified OPC-167832 as having potent antituberculosis activity. The MICs of the compound for ranged from 0.

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[reaction: see text] Concise synthesis of defucogilvocarcin M was achieved via the [2 + 2 + 2] approach to beta-phenylnaphthalene structure.

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