Acute liver damage and interaction of cisplatin with silver nanoparticles depend on particle size.

Nanomaterials are innovative materials that have novel properties that differ from those of macroscale materials in terms of response to stimuli such as heat, light, and voltage. However, the potential unknown effects of nanomaterials on living organisms have raised concerns. There are few reports describing the effects of silver nanoparticles on living organisms and the effects of nanoparticle interactions with chemical substances such as pharmaceuticals.

Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis.

Tob is a recently reported novel bone morphogenetic protein (BMP) inhibitor, which originally was identified by West-Western procedure using ErbB2 as a probe and contains a nuclear localization signal. To further characterize the effects of Tob deficiency on BMP-induced new bone (NB) formation, we examined microcomputed tomography (microCT) on the cross-section of the bone induced by daily injection with BMP onto the calvariae of newborn mice. The calvariae of the saline-injected Tob-deficient (TD) mice were similar to those of the saline-injected or untreated wild-type (WT) mice.