Ovariectomy and gonadal hormone treatment: effects on insulin-like growth factor-1 receptors in the rat brain.

Various studies demonstrate that estradiol regulates structure and function of adult neurons. Long-term effect of estradiol in terms of neuroprotection is less documented compared to short-term one. It is well documented that estradiol interacts with insulin-like growth factor-1 (IGF-I) in the brain.