Estimating and monitoring laser-induced damage size on glass windows with a deep-learning-based pipeline.

Laser-induced damage is a major issue in high power laser facilities such as the Laser MégaJoule (LMJ) and National Ignition Facility (NIF) since they lower the efficiency of optical components and may even require their replacement. This problem occurs mainly in the final stages of the laser beamlines and in particular in the glass windows through which laser beams enter the central vacuum chamber. Monitoring such damage sites in high energy laser facilities is, therefore, of major importance.

Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis.

The uterine lining (endometrium) exhibits a pro-inflammatory phenotype in women with endometriosis, resulting in pain, infertility, and poor pregnancy outcomes. The full complement of cell types contributing to this phenotype has yet to be identified, as most studies have focused on bulk tissue or select cell populations. Herein, through integrating whole-tissue deconvolution and single-cell RNAseq, we comprehensively characterized immune and nonimmune cell types in the endometrium of women with or without disease and their dynamic changes across the menstrual cycle.