Publications by authors named "Isam Adam"
Article Synopsis
- - The circadian clock plays a crucial role in regulating the immune system and is important for both disease defense and cancer detection.
- - Research using single-cell RNA sequencing reveals that certain immune cells, particularly PD-L1-expressing myeloid-derived suppressor cells (MDSCs), oscillate in numbers based on the time of day and suppress the activity of CD8 T cells.
- - Timing the administration of anti-PD-L1 treatment to coincide with the peak levels of MDSCs enhances its effectiveness, highlighting the importance of circadian rhythms in cancer immunotherapy.
Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but patients relapse, highlighting the need to understand the mechanisms of resistance. We discovered that in primary breast cancer, tumor cells that resist T cell attack are quiescent. Quiescent cancer cells (QCCs) form clusters with reduced immune infiltration.
View Article and Find Full Text PDFInherent plasticity and various survival cues allow glioblastoma stem-like cells (GSCs) to survive and proliferate under intrinsic and extrinsic stress conditions. Here, we report that GSCs depend on the adaptive activation of ER stress and subsequent activation of lipogenesis and particularly stearoyl CoA desaturase (SCD1), which promotes ER homeostasis, cytoprotection, and tumor initiation. Pharmacological targeting of SCD1 is particularly toxic due to the accumulation of saturated fatty acids, which exacerbates ER stress, triggers apoptosis, impairs RAD51-mediated DNA repair, and achieves a remarkable therapeutic outcome with 25%-100% cure rate in xenograft mouse models.
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