Alosetron does not affect the visceral perception of gastric distension in healthy subjects.

Background: The effect of alosetron, a new specific 5-HT3 receptor antagonist, on the visceral perception in response to gastric distension was assessed in 12 healthy male subjects in a randomized, double-blind, placebo controlled crossover trial.

Methods: Each subject was given orally either alosetron 1 mg b.d.

The clinical development of ondansetron for use in the prevention and treatment of postoperative nausea and vomiting.

An international clinical trial programme has been established to assess the efficacy and safety of ondansetron in the prevention and treatment of postoperative nausea and vomiting. The programme included nine pilot studies and six key placebo-controlled studies. These studies have evaluated both oral and intravenous formulations of ondansetron in the prevention of postoperative nausea and vomiting, and intravenously administered ondansetron in the treatment of established symptoms.

Double blind multicentre comparison of omeprazole 20 mg once daily versus ranitidine 150 mg twice daily in the treatment of cimetidine or ranitidine resistant duodenal ulcers.

The purpose of the present study was to compare omeprazole 20 mg once daily and ranitidine 150 mg twice daily in healing duodenal ulcers unhealed by previous treatment with cimetidine greater than or equal to 0.8 g or ranitidine greater than or equal to 0.3 g daily for at least six weeks.

[Omeprazole (20 mg daily) compared to ranitidine (150 mg twice daily) in the treatment of esophagitis caused by reflux. Results of a double-blind randomized multicenter trial in France and Belgium].

We report the results of a trial of omeprazole 20 mg daily versus ranitidine 150 mg b.i.d.

[Comparative efficacy of omeprazole and cimetidine in the treatment of duodenal ulcer in the acute stage. A French multicenter, controlled therapeutic trial].

Omeprazole is a proton pump inhibitor which induces a dose-dependent reduction of gastric acid secretion. To assess its efficacy in healing and alleviating the symptoms of duodenal ulcer, a randomized and double-blind study was conducted in 26 French centers comparing omeprazole 20 mg o.m.

Low dose omeprazole effects on gastric acid secretion in normal man.

The pharmacological effects of low dose of omeprazole (Om) are not well known. This prompted us to investigate the effects of a 7-day treatment with a low dose of Om, 10 mg/d (Om10), on gastric acid secretion and serum gastrin levels and to compare the results with those obtained with an effective antisecretory dose of 20 mg/d (Om20). Twelve healthy volunteers received randomly and double-blind for three periods of 7 days, separated by at least 7 days, one capsule of placebo (P), Om10, Om20, given daily in the morning, in fasting condition.

Effectiveness of omeprazole in seven patients with Zollinger-Ellison syndrome resistant to histamine H2-receptor antagonists.

The inhibitory effect of omeprazole, a benzimidazole derivative, on gastric acid secretion was investigated in seven patients with Zollinger-Ellison syndrome resistant to treatment with large doses of histamine H2-receptor antagonists administered alone or in combination with pirenzepine. In two patients with an acute form of the syndrome, rapid control of acid overproduction was achieved with 180-mg intravenous and 120-mg oral daily doses, respectively. The other five patients, who were free of complication, initially received a standard regimen of omeprazole 60 mg orally once a day; dosage was subsequently adjusted until the basal acid output, measured 1 hr before the next dose of the drug, was less than 10 mmol/hr.

[Serum lipoproteins in chronic alcoholics. Changes in HDL, VLDL and LDL as a function of the degree of hepatic involvement].

Changes in lipoprotein fractions HDL and LDL-VLDL were investigated in 84 chronic alcoholic patients and attempts were made to correlate these changes with the severity of liver damage. In 40 patients with undetectable hepatic lesions the lipoprotein fractions were not reduced but a rapidly reversible increase in HDL was noted in 15%. The 14 patients with steatosis and alcoholic hepatitis showed a fall in HDL, often associated with an increase in plasma triglycerides; these changes regressed during weaning.

[Radiotelemetric study of the effects of antacids and cimetidine on intragastric pH (author's transl)].

Radiotelemetric measurement of intragastric pH constitutes a simple method for assessing the activity of surface antacids and antisecretory agents in man. The time during which the intragastric pH is maintained at 3.5 or above is the bet criterion of therapeutic effectiveness.