Pharmacological composition based on bacteriocinnisin in experiments and .

Background: Antibiotic resistance is a global health problem related to the transmission of bacteria and genes between humans and animals. The development of new drugs with antimicrobial activity research is an urgent task of modern science.

Aim: The article presents data of and experiments on new pharmaceutical composition based on nisin.

Effects of combined exposure to modeled radiation and gravitation factors of the interplanetary flight: Monkeys' cognitive functions and the content of monoamines and their metabolites; cytogenetic changes in peripheral blood lymphocytes.

In a study on primates (Macaca mulatta), neurobiological and radiobiological effects have been studied of the synchronous combined action of 7-day antiorthostatic hypokinesia and exposure of the monkeys' head first to γ-rays during 24 h and then to accelerated C ions. The neurobiological effects were evaluated by the cognitive functions which model the basic elements of operator activity and the concentration of monoamines and their metabolites in peripheral blood. The radiobiological effects were evaluated by the chromosomal aberration and DNA double-strand break (DSB) yield in peripheral blood lymphocytes.

[STAGES OF OPIOID THERAPY OF CHRONIC PAIN IN RUSSIA: ANCIENT AND COMING].

There is history of the introduction and development of systemic and invasive opioid treatment of chronic cancer pain in Russia presented by the authors--experts with experience in thisfield over 30 years. The earliest researchers are no more among us, but their memory is still alive in the publications of the early 1980's. Along with the analysis of accumulated by Russian specialists positive clinical experience of opioids using, authors discuss main problems of organization and availability of adequate opioid therapy of chronic pain in Russia.

[Evaluation of the efficiency and safety of therapy with a combination of sulfonylurea derivatives and insulin sensitizers for type 2 diabetes mellitus].

Aim: To evaluate the efficiency and safety of early combination therapy with sulfonylurea derivatives (SUD) and insulin sensitizers in patients with type 2 diabetes mellitus (T2DM).

Subjects And Methods: Forty patients (31 women and 9 men; mean age 57.7 +/- 0.

[The level of endogenous prostaglandins in adolescents with duodenal peptic ulcer in relation to the phase of the disease].

Sixty-seven adolescents suffering from duodenal ulcer (DU) were studied for the level of prostaglandins (PG) E and P2 alpha in the gastric juice and blood plasma depending on the condition of the gastric juice hydrochloric acid secretion and phase of the disease. There were no significant differences in PG content in adolescents with hyper- and normal acidity or subacidity. During the stage of aggravation PG level gets significantly increased and remains somewhat elevated during remission.

[Changes in the concentration of beta-endorphin in the cerebrospinal fluid due to morphine analgesia in incurable oncologic patients].

Thirty cancer patients, clinical group IV, have been examined. It has been established that a persistent pain syndrome leads to lowering in beta-endorphin liquor level. Morphine analgesia is followed by beta-endorphin level elevation which directly depends on pain intensity and analgesia efficacy.

[Architectonics of the vascular bed of the fetal portion of the mature human placenta (based on data of scanning electron microscopy)].

Peculiarities of the microangioarchitectonics in the trunks, intermediate and terminal villi of the placenta have been described at a noncomplicated pregnancy. Signs of neovasculogenesis are demonstrated in the microcirculatory bed of the terminal villi. Possible connection between reduction of the paravasal capillary network, as the intermediate villi become mature, and neovasculogenesis is discussed.

[Pathomorphology and ultrastructure of the placenta in abortion].

Pathologic background has been evaluated for premature delivery of 38-39, 30-37 and 20-27 week fetuses. The trial involved 115 placentas in abortion and 60 control cases of normal pregnancy. A combination of modern techniques involving histological, enzymatic and chemical has been employed as well as light microscopy.

[Treatment of the pain syndrome in cancer patients by peridural administration of low doses of opiates].

Peridural injections of morphine were given to 180 incurable cancer patients suffering chronic pain. The effectiveness of the said procedure as well as its side-effects were assessed. A relationship between the external respiration parameters, on the one hand, and drug dosage and time postinjection, on the other, was studied.

[Antibodies to polysaccharides of group A Streptococcus in patients with rheumatism after mitral commissurotomy].

Gel precipitation was employed to detect antibodies to the A-polysaccharide specific antigenic determinant in blood serum of 131 patients with different versions of rheumatic fever. 21 patients with non-rheumatic myocarditis, 25 convalescents following quinsy, and 58 donors. It was established that high titers of antibodies to A-polysaccharide in patients with protracted and latent rheumatic fever correlate with the clinical and morphological signs of the process activity.