Publications by authors named "Isak Martinson"
Mol Neurodegener
September 2022
Article Synopsis
- ApoE is crucial for lipid and cholesterol transport in the central nervous system (CNS), with three main variations (apoE2, apoE3, apoE4), where APOE4 significantly increases the risk of late-onset Alzheimer's disease (AD).
- The review explores the evolution of apoE and how its genetic variations affect its function and structure, influencing key aspects of AD pathology like neuroinflammation, amyloid-β accumulation, and tau-related issues.
- Additionally, the text examines how APOE genotype interacts with factors like age, sex, diet, and therapies in AD and its role in other neurodegenerative diseases marked by inflammation, broadening the understanding of APOE's impact on CNS health.
