Publications by authors named "Isaiah A A Neve"
Article Synopsis
- The genotype-phenotype relationship in animals can be significantly influenced by microbial environments, which provide key metabolic cues.
- Different bacterial strains, like B strain OP50 and K-12 strain MG1655, induce varied cellular, developmental, and behavioral phenotypes in host organisms.
- Specific metabolites, particularly betaine levels from these bacteria, impact fat storage traits and mitochondrial morphology, highlighting the need to consider microbial contributions when studying genetic effects on physiology.
Aging is fundamental to life and reflects functional declines in different tissues at the organismal level. As a systematic process, aging can be influenced by the interplay between genetic and environmental factors, and the nervous system plays a crucial role in this regulation. Environmental inputs can be sensed by the nervous system, which consequently triggers signaling outputs toward peripheral tissues to regulate gene expression systematically.
View Article and Find Full Text PDFHomeostasis of the gut microbiota critically influences host health and aging. Developing genetically engineered probiotics holds great promise as a new therapeutic paradigm to promote healthy aging. Here, through screening 3,983 Escherichia coli mutants, we discovered that 29 bacterial genes, when deleted, increase longevity in the host Caenorhabditis elegans.
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