Secular trends of candidemia at a Brazilian tertiary care teaching hospital.

Background: Candidemia is the most frequent invasive fungal disease in hospitalized patients, and is associated with high mortality rates. The main objective of this study was to evaluate changes in the epidemiology of candidemia at a tertiary care hospital in a 21-year period.

Methods: We evaluated all episodes of candidemia diagnosed between 1996 and 2016 at a University-affiliated tertiary care hospital in Brazil.

[Adherence to international guidelines on early management in severe sepsis and septic shock].

Introduction: Complete adherence to early goal-directed therapy has shown a significant reduction in 28-day mortality rate, whereas partial adherence has not shown beneficial effect.

Objectives: The effect of adherence to 6 hour sepsis bundle treatment was evaluated on patients with severe sepsis and septic shock.

Materials And Methods: A prospective cohort study was conducted during a six-month period.