Circadian rhythm of blood pressure reflects the severity of cardiac impairment in familial amyloid polyneuropathy.

Background: Cardiac amyloidosis due to familial amyloid polyneuropathy (FAP) includes restrictive cardiomyopathy, thickened cardiac walls, conduction disorders and cardiac denervation. Impaired blood pressure variability has been documented in FAP related to the Val30Met mutation.

Aims: To document blood pressure variability in FAP patients with various mutation types and its relationship to the severity of cardiac involvement.