Publications by authors named "Isabelle Straumann"
Article Synopsis
- MDMA (ecstasy) is being studied as a treatment for PTSD but has the risk of causing low sodium levels (hyponatremia) after just one dose due to factors like vasopressin release and excessive drinking.
- This study aimed to analyze how often and severely hyponatremia occurs after a single MDMA dose, looking at underlying hormonal mechanisms and whether limiting fluid intake could reduce this risk.
- Out of 96 participants, about 31% experienced hyponatremia, but none in the group with fluid restrictions, suggesting that managing fluid intake could lessen the chance of developing this complication.
Article Synopsis
- - Classic psychedelics like mescaline have renewed interest in therapy, but there's limited modern data on its effects and mechanisms of action in humans due to a lack of comprehensive studies.
- - In a study with 16 healthy participants, mescaline was administered in varying doses (100-800 mg) to assess subjective and autonomic effects, showing that higher doses produced stronger effects, increased heart rate, and elevated blood pressure without notable differences between doses above 100 mg.
- - The combination of mescaline and the 5-HT receptor antagonist ketanserin decreased and shortened the effects of the highest dose, suggesting the acute effects of mescaline are mainly mediated by these serotonin receptors, while nausea was a common
The pharmacodynamic effects of lysergic acid diethylamide (LSD) are diverse and different in different individuals. Effects of other psychoactive substances have been shown to be critically influenced by non-pharmacological factors such as personality traits and mood states. The aim of this study was to determine pharmacological and psychological predictors of the LSD effects in healthy human subjects.
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- MDMA, known for boosting mood and empathy, was compared with its enantiomers S-MDMA and R-MDMA in a controlled study to explore their effects on participants' experiences of stimulation and psychedelia.
- S-MDMA (125 mg) produced stronger subjective effects and increased blood pressure compared to both R-MDMA doses and regular MDMA, while R-MDMA did not show notable psychedelic effects as expected.
- Pharmacokinetic analysis revealed that S-MDMA has a shorter elimination half-life (4.1 hours) and results in higher plasma levels of prolactin, cortisol, and oxytocin compared to R-MDMA, which has a longer half-life (12-14 hours) and weaker stimulant
Derivatization-free determination of chiral plasma pharmacokinetics of MDMA and its enantiomers.
J Chromatogr B Analyt Technol Biomed Life Sci
May 2024
3,4-Methylenedioxymethamphetamine (MDMA) is an entactogen with therapeutic potential. The two enantiomers of MDMA differ regarding their pharmacokinetics and pharmacodynamics but the chiral pharmacology of MDMA needs further study in clinical trials. Here, an achiral and an enantioselective high performance liquid chromatography-tandem mass spectrometry method for the quantification of MDMA and its psychoactive phase I metabolite 3,4-methylenedioxyamphetamine (MDA) in human plasma were developed and validated.
View Article and Find Full Text PDFThere is renewed interest in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. Although acute subjective effects of LSD are mostly positive, negative subjective effects, including anxiety, may occur. The induction of overall positive acute subjective effects is desired in psychedelic-assisted therapy because positive acute experiences are associated with greater therapeutic long-term benefits.
View Article and Find Full Text PDFMescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic psychedelics. A valid, direct comparison of the effects of these substances is lacking. The main goal of the present study was to investigate potential pharmacological, physiological and phenomenological differences at psychoactive-equivalent doses of mescaline, LSD, and psilocybin.
View Article and Find Full Text PDFN,N-dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics because of its short-lasting effects when administered intravenously. Despite growing interest in the experimental and therapeutic use of intravenous DMT, data are lacking on its clinical pharmacology. We conducted a double-blind, randomized, placebo-controlled crossover trial in 27 healthy participants to test different intravenous DMT administration regimens: placebo, low infusion (0.
View Article and Find Full Text PDF3,4-Methylenedioxymethamphetamine (MDMA) has shown initial promise as an adjunct in psychotherapy to treat posttraumatic stress disorder (PTSD). Its efficacy and safety have been demonstrated across phase I-III studies. However, the mechanism underlying the potential utility of MDMA to treat PTSD in humans has not yet been thoroughly investigated.
View Article and Find Full Text PDFGrowing interest has been seen in using lysergic acid diethylamide (LSD) and psilocybin in psychiatric research and therapy. However, no modern studies have evaluated differences in subjective and autonomic effects of LSD and psilocybin or their similarities and dose equivalence. We used a double-blind, randomized, placebo-controlled, crossover design in 28 healthy subjects (14 women, 14 men) who underwent five 25 h sessions and received placebo, LSD (100 and 200 µg), and psilocybin (15 and 30 mg).
View Article and Find Full Text PDFLysergic acid diethylamide (LSD) is a classic psychedelic substance that is used recreationally and investigated in psychiatric research. There are no pharmacogenetic studies on LSD. In vitro metabolic studies indicate that several cytochrome P450 (CYP) isoforms (e.
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