Disseminated Emergomycosis in a Person with HIV Infection, Uganda.

We describe emergomycosis in a patient in Uganda with HIV infection. We tested a formalin-fixed, paraffin-embedded skin biopsy to identify Emergomyces pasteurianus or a closely related pathogen by sequencing broad-range fungal PCR amplicons. Results suggest that emergomycosis is more widespread and genetically diverse than previously documented.

Cytomegalovirus reactivation in patients with refractory checkpoint inhibitor-induced colitis.

Objectives: Immune checkpoint inhibitors can cause severe immune-related adverse events, with immune-related diarrhea and colitis (irColitis) being among the most frequent ones. While the majority of patients with irColitis respond well to corticosteroid treatment ± other immunomodulatory drugs such as infliximab, some patients do not show resolution of their symptoms. In the present study, we analysed the frequency of therapy-refractory irColitis, the underlying cause, and useful diagnostic approaches.

Cutaneous leukocytoclastic vasculitis: the role of lymphocytes and related immune markers.

Introduction: Apart from neutrophils, other immune cells may play a significant pathogenetic role in cutaneous leukocytoclastic vasculitis (CLV).

Aim: To investigate lymphocytes and related immunological factors in patients with CLV requiring systemic glucocorticosteroid treatment.

Material And Methods: Fourteen patients with severe idiopathic CLV were treated with systemic prednisolone in a tapered dose regimen.