Toxic epidermal necrolysis associated with pembrolizumab.

Introduction: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe cutaneous drug eruptions characterized by epidermal detachment. Pembrolizumab is a monoclonal antibody that binds to the programmed death-1 receptor, and it has been associated with numerous cutaneous adverse side-effects, including Stevens-Johnson syndrome.

Case Report: We describe a 63-year-old male with metastatic lung adenocarcinoma who developed a rapidly progressing maculopapular rash three days after a first dose of pembrolizumab.

Necrolytic Migratory Erythema: A Forgotten Paraneoplastic Condition.

Background: Necrolytic migratory erythema (NME) is most commonly a paraneoplastic condition. It is the dermatologic manifestation classically associated with glucagonoma pancreatic neuroendocrine tumour. Glucagonoma syndrome has been defined by the constellation of secreting tumour associated with overproduction by the α-cells in the pancreatic islets of Langerhans, abnormally elevated blood level of glucagon, and skin findings of NME.

Treatment of nail psoriasis with intralesional triamcinolone acetonide using a needle-free jet injector: a prospective trial.

Background: Treating nail psoriasis is challenging. Corticosteroid matrix injection with needle is a conventional treatment but pain is often a limitation.

Objective: Evaluate efficacy and safety of triamcinolone acetonide needle-free injection with the Med-Jet MBX in psoriatic fingernail.

Physician survey regarding patient nonattendance at follow-up appointments at a university-affiliated medical dermatology clinic.

Background: Patient nonattendance is a frequent occurrence in dermatology clinics, and our responsibility regarding the follow-up of these patients remains nebulous.

Objective: This study sought to evaluate the beliefs and practices of physicians at a university-affiliated medical dermatology clinic regarding patient nonattendance at follow-up appointments and to provide an algorithm to deal appropriately with absentee patients based on various Canadian medical association guidelines.

Methods: A questionnaire was distributed to the 17 dermatologists practicing at the Centre Hospitalier de l'Université de Montréal medical dermatology clinic.

Attitudes and subjective norms of male and female adolescents toward breastfeeding.

There is a lack of information regarding the attitudes of Québec's adolescents about breastfeeding and how others influence their opinions. The present study aims to describe attitudes and subjective norms of adolescent males and females toward breastfeeding and to determine whether these are related to gender, age, secondary education level, mother tongue, country of origin, feeding method as an infant, feeding method of siblings, and exposure to breastfeeding. Adolescents (N = 439) answered a questionnaire based on the theory of reasoned action.

Translation and validation of a French version of Brown's Support Behaviors Inventory in perinatal health.

This article describes the process used for translation, testing for reliability and validity, and establishing factor structure of a French version of Brown's Support Behaviors Inventory (SBI-Fr). The objective was to provide an adequate self-report measure of satisfaction with social support during the perinatal period for use with a Francophone population in Québec, Canada. When compared with the English version, the French version had similar qualities regarding reliability and validity, but principal component analysis (N = 271) revealed that the SBI-Fr measures two distinct subscales, perceived satisfaction with partner's and others' support.

Incidence and risk factors associated with a second squamous cell carcinoma or basal cell carcinoma in psoralen + ultraviolet a light-treated psoriasis patients.

Psoralen + ultraviolet A-treated psoriasis patients are at increased risk for squamous cell carcinomas and basal cell carcinomas; however, the incidence and risk factors associated with second squamous cell carcinomas and basal cell carcinomas in this population are not well qualified. Incidence and risk factors for second squamous cell carcinomas and basal cell carcinomas were studied in a cohort of 1380 psoralen + ultraviolet A-treated psoriasis patients prospectively followed for over 20 y; 264 had a squamous cell carcinoma and 258 a basal cell carcinoma after beginning psoralen + ultraviolet A therapy. After a first squamous cell carcinoma, the risk of a second squamous cell carcinoma was 26% at 1 y, 62% at 5 y, and 75% at 10 y.