Publications by authors named "Isabelle Mangeot"
Dendritic cells (DCs) are professional antigen-presenting cells whose functions are dependent on their degree of differentiation. In their immature state, DCs capture pathogens and migrate to the lymph nodes. During this process, DCs become resident mature cells specialized in antigen presentation.
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- The study tested a prime/boost HIV vaccine strategy using 5 lipopeptides (HIV-Lipo-5) and a modified vaccinia virus (rMVA-HIV) in cynomolgus macaques.
- Both vaccine components showed excellent safety, with HIV-Lipo-5 significantly raising anti-HIV antibody levels, while strong T-cell responses needed the combination with rMVA-HIV, particularly against the Gag antigen.
- The results suggest that using HIV-Lipo-5 for initial priming followed by rMVA-HIV as a booster could be an effective strategy for preventing or treating HIV/AIDS.
Chronic hepatitis C virus (HCV) infection, with its cohort of life-threatening complications, affects more than 200 million persons worldwide and has a prevalence of more than 10% in certain countries. Preventive and therapeutic vaccines against HCV are thus much needed. Neutralizing antibodies (NAbs) are the foundation for successful disease prevention for most established vaccines.
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