Publications by authors named "Isabelle Ludwikoski"
Article Synopsis
- The human skin microbiome acts as a protective barrier against pathogens by producing antimicrobial substances, making it a valuable resource for discovering new natural products.
- Researchers introduced the EPithelial Isolate Collection (EPIC), which comprises 980 diverse bacterial strains from human skin across eight body sites, including many rare strains with unique biosynthetic gene clusters (BGCs).
- Through extensive testing, they found that this microbiome exhibits strong antifungal properties, with certain body sites showing higher potential for discovering new bioactive compounds, leading to advancements in antimicrobial drug development and microbiome research.
Fungi and bacteria are ubiquitous constituents of all microbiomes, yet mechanisms of microbial persistence in polymicrobial communities remain obscure. Here, we examined the hypothesis that specialized fungal survival structures, chlamydospores, induced by bacterial lipopeptides serve as bacterial reservoirs. We find that symbiotic and pathogenic gram-negative bacteria from non-endosymbiotic taxa enter and propagate in chlamydospores.
View Article and Find Full Text PDFFungal secondary metabolites (SMs) have captured the interest of natural products researchers in academia and industry for decades. In recent years, the high rediscovery rate of previously characterized metabolites is making it increasingly difficult to uncover novel compounds. Additionally, the vast majority of fungal SMs reside in genetically intractable fungi or are silent under normal laboratory conditions in genetically tractable fungi.
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