Publications by authors named "Isabelle Luchsinger"
Topical corticosteroids (TCS) are the mainstay of therapy for paediatric atopic dermatitis (AD). The use of TCS is often met with fear by parents. Assessing this parental TCS fear in clinical practice is still lacking.
View Article and Find Full Text PDFDeep venous thrombosis (DVT) poses a substantial disease burden. Lymphedema may present with similar symptoms making the diagnosis process more difficult. Data on the epidemiology of lymphedema are lacking.
View Article and Find Full Text PDFBackground: Chronic prurigo (CPG) presents with pruriginous lesions and reduced quality of life (QoL). Established treatment options are often unsatisfying. Little is known about the efficacy of topical occlusive treatments.
View Article and Find Full Text PDFObjective: To investigate the efficacy of educational videos using storytelling to reduce parents' fear of topical corticosteroid (TCS) use in children affected by atopic dermatitis (AD).
Methods: Children aged 0 to 5 years who had AD were included. The primary outcome measures were parental fear of TCSs, as determined by Topical Corticosteroid Phobia score, and quality of life according to the Family Dermatology Life Quality Index.
Article Synopsis
- Costello syndrome is a severe neurodevelopmental disorder linked to changes in the HRAS gene, mostly involving codons 12 and 13, leading to a consistent phenotype in affected individuals.
- This report discusses a unique subgroup from one family with a less severe form linked to a specific HRAS variant (c.176C>T p.(Ala59Gly)), which hasn't been documented before in other patients.
- The individuals exhibit mild ectodermal issues and show no major health concerns, pointing to a new, milder form of HRAS-related disorders compared to classical Costello syndrome, suggesting the need for a new classification for such cases.
Hintergrund Und Ziele: Molluscum contagiosum (MC) ist eine häufige Virusinfektion der Haut. Bei gewissen Patienten mit MC kann eine Hypersensitivitätsreaktion ähnlich des Gianotti-Crosti-Syndroms beobachtet werden. Diese wird Gianotti-Crosti syndrome-like reaction (GCLR, Gianotti-Crosti-Syndrom-ähnliche Reaktion) genannt.
View Article and Find Full Text PDFBackground And Objectives: Molluscum contagiosum (MC) is a common viral infection. Hypersensitivity reactions reminiscent of Gianotti-Crosti syndrome, termed Gianotti-Crosti syndrome-like reaction (GCLR), have been reported in a subset of patients. We report a series of patients with GCLR, better delineating its clinical presentation and course.
View Article and Find Full Text PDFArticle Synopsis
- Sleep problems in infants treated with propranolol for hemangiomas may indicate potential central nervous system effects; however, this study objectively compares the sleep behavior of treated infants with healthy controls.
- The study involved 54 infants in both groups monitored for sleep using actigraphy and diaries over 7-10 days at 3 and 6 months; findings at 6 months showed treated infants had decreased sleep efficiency and more nighttime awakenings.
- Despite these changes, 24-hour total sleep remained stable, and no negative impact on subjective sleep quality or behavioral development was observed, supporting the use of propranolol as a first-line treatment for infantile hemangiomas.
We report the case of a 10-year-old girl with bullous Sweet syndrome, recalcitrant to high-dose systemic corticosteroids. Subsequent treatment with infliximab resulted in a rapid improvement in cutaneous lesions and systemic symptoms. Cutis laxa was noted in the healed skin.
View Article and Find Full Text PDFImportance: Netherton syndrome (NS) is a rare, severe genetic disorder of cornification with high morbidity. Treatment for NS has been notoriously difficult. Recent studies showed an upregulated helper T cell (TH) 17/interleukin 23 (IL-23) pathway in NS, suggesting the possibility of treatment strategies that target IL-17.
View Article and Find Full Text PDFCongenital hemangiomas are vascular tumors that are fully formed at birth, typically without postnatal growth. Noninvoluting congenital hemangiomas (NICH) have a distinctive clinical, radiologic, and histopathological profile and lack of expansion or involution over time. Herein, we describe two cases of NICH with atypical postnatal growth.
View Article and Find Full Text PDFBackground: Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare disorder, and its pathogenesis and long-term prognosis are unknown.
Objective: To elucidate the clinical and histopathologic characteristics, pathogenesis, and outcome in patients with SHJCM.
Methods: Retrospective study of 9 patients with SHCJM.
Objective: Investigation on recent cases of tinea genitalis after travelling to South East Asia.
Methods: Patients with tinea in the genital region, which emerged after sex in South East Asia, underwent further assessment including microscopy, cultures and DNA analyses.
Results: The case series includes seven patients.