Publications by authors named "Isabelle Lambermont"
Phosphatidylinositol 3-kinase (PI 3-kinase) and its target protein kinase B (Akt) are involved in various processes including internalization, chemotaxis and proliferation. We analysed the activation of Akt in J774 macrophages infected with virulent (pYV+) or avirulent (pYV-) Yersinia enterocolitica. During the early stage of infection with pYV+ and pYV- bacteria, Akt and its targets, glycogen synthase kinase 3 (GSK-3) and forkhead transcription factor (FKHRL1), became phosphorylated.
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- Yersinia spp. strains use a type III secretion system to inject Yop effector proteins into human cells, particularly influencing inflammatory responses.
- The study focused on human umbilical vein endothelial cells (HUVECs) and found that the YopP protein significantly downregulates the expression of adhesion molecules and cytokines involved in inflammation.
- Notably, high-virulence Yersinia enterocolitica strains (biotype 1B) were more effective at inhibiting inflammatory responses compared to low-virulence strains, with the degree of inhibition dependent on the contact duration and strain characteristics.