Publications by authors named "Isabelle Kaneza"
Article Synopsis
- Jet lag causes sleepiness and memory loss due to disruption of our internal body clock, affecting many people, especially when focus is necessary.
- Researchers studied male mice in different seasonal light conditions (winter, summer, equinox) to understand how jet lag recovery and memory are influenced by changes in daylight.
- They found that exposure to light, which can improve or impair memory based on its timing, plays a significant role in jet lag recovery, suggesting that adjusting light exposure could help treat jet lag more effectively.
Alcohol's impairment of both hepatic lipid metabolism and insulin resistance (IR) are key drivers of alcoholic steatosis, the initial stage of alcoholic liver disease (ALD). Pharmacologic reduction of lipotoxic ceramide prevents alcoholic steatosis and glucose intolerance in mice, but potential off-target effects limit its strategic utility. Here, we employed a hepatic-specific acid ceramidase (ASAH) overexpression model to reduce hepatic ceramides in a Lieber-DeCarli model of experimental alcoholic steatosis.
View Article and Find Full Text PDFLipid droplets (LDs) are bioactive organelles found within the cytosol of the most eukaryotic and some prokaryotic cells. LDs are composed of neutral lipids encased by a monolayer of phospholipids and proteins. Hepatic LD lipids, such as ceramides, and proteins are implicated in several diseases that cause hepatic steatosis.
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