Studies are needed to support optimal insulin dose titration in gestational diabetes mellitus: A systematic review.

Background And Aims: We aimed to summarise the existing literature on insulin dose titration in gestation diabetes.

Methods: Databases: Medline, EMBASE, CENTRAL and CINAHL were systematically searched for trials and observational studies comparing insulin titration strategies in gestational diabetes.

Results: No trials comparing insulin dose titration strategies were identified.

Common genetic variants with fetal effects on birth weight are enriched for proximity to genes implicated in rare developmental disorders.

Birth weight is an important factor in newborn survival; both low and high birth weights are associated with adverse later-life health outcomes. Genome-wide association studies (GWAS) have identified 190 loci associated with maternal or fetal effects on birth weight. Knowledge of the underlying causal genes is crucial to understand how these loci influence birth weight and the links between infant and adult morbidity.