Publications by authors named "Isabelle Johnson"
Article Synopsis
- Pioneer transcription factors, like TCF-1, can access silent chromatin to influence gene programs specific to certain cell types during development.
- The study finds that removing a specific disordered region (L1) from TCF-1 causes a developmental block in T cells and results in incorrect lineage expression.
- The L1 region is crucial for TCF-1's ability to activate T cell genes and suppress genes usually associated with mast cells and dendritic cells, indicating its role in maintaining proper T cell lineage identity.
We characterized a prospective endometrial carcinoma (EC) cohort containing 138 tumors and 20 enriched normal tissues using 10 different omics platforms. Targeted quantitation of two peptides can predict antigen processing and presentation machinery activity, and may inform patient selection for immunotherapy. Association analysis between MYC activity and metformin treatment in both patients and cell lines suggests a potential role for metformin treatment in non-diabetic patients with elevated MYC activity.
View Article and Find Full Text PDFMulti-enhancer hubs are spatial clusters of enhancers present across numerous developmental programs. Here, we studied the functional relevance of these three-dimensional structures in T cell biology. Mathematical modeling identified a highly connected multi-enhancer hub at the Ets1 locus, comprising a noncoding regulatory element that was a hotspot for sequence variation associated with allergic disease in humans.
View Article and Find Full Text PDF