Publications by authors named "Isabelle Goubin-Versini"

Article Synopsis
  • * The study presents three new cases of XX/XY chimeras, including a boy with an ovary in an abnormal gonad and two infertile men who appeared phenotypically normal.
  • * These cases emphasize the need for various cytogenetic and molecular tests across different tissues to accurately diagnose and predict outcomes for individuals with chimerism.
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Background: Few data are available on programmed cell-death-protein-1-ligand-1 (PD-L1) expression on large-cell neuroendocrine carcinomas of the lung (LCNECs). We analyzed PD-L1 expression on tumor (TCs) and inflammatory cells (ICs) from LCNEC patients to assess relationships between this expression, clinical characteristics, and disease outcomes.

Methods: PD-L1 expression was determined by immunohistochemistry with monoclonal antibody 22C3 in consecutive LCNEC patients managed in 17 French centers between January 2014 and December 2016.

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The prognostic value of cell of origin (COO) classification and BCL2 expression is not well established in diffuse large B-cell lymphoma (DLBCL) patients with human immunodeficiency virus (HIV) infection in the recent era. Phenotypic patterns were determined by immunohistochemistry (IHC) of pathological samples from patients with HIV-associated DLBCL prospectively enrolled in the French AIDS and Viral Hepatitis CO16 Lymphovir cohort between 2008 and 2015. Molecular subgroup classification into germinal centre B-cell (GCB) and non-GCB subtypes was determined using the Hans algorithm.

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Objective: The primary aim of our study was to determine the prevalence of macroscopic deciduosis Found randomly in Cesarean sections and the secondary objective to determine the association with any obstetrical complications or adverse effects.

Methods: This is a unicenter prospective study from 01/08/2011 to 01/02/2014. During the study period 307 consecutive Cesarean sections were performed with 31 biopsy proven cases of macroscopic deciduosis in the ovary, uterine and fallopian tube serosa.

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Article Synopsis
  • May-Grünwald-Giemsa (MGG) stain is an essential Romanowsky-type stain used in both hematology and cytopathology for examining air-dried cell samples.
  • A 2013 proficiency test conducted by French organizations updated the MGG staining process, highlighting steps like rapid air-drying, specific fixation times, and two-step staining techniques.
  • Quality assessment focuses on red blood cells and leukocytes, with specific color indicators, while automated slide stainers are recommended for consistency; Diff-Quik(®) can be an alternative for quick evaluations.
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When considering the number of thyroid fine-needle aspirations performed not only in France but also in the world, then thyroid pathology, as well as Pap smears, represents the main pathology based on cytological diagnoses. Decisions of clinical follow-up or of surgical treatments will be done based on the cytological results. Until recently, neither official nor consensual terminology has been adopted despite classifications by experts having been proposed.

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Malignant deciduoid mesothelioma, a rare phenotype of epithelioid mesothelioma, arises more commonly from the peritoneum of young women, but it is also reported in the pleura of elderly people. We report a case of malignant deciduoid mesothelioma that occurred in a 41-year-old woman after cesarean section and was initially misdiagnosed as pseudotumoral deciduosis. Microscopically, the tumor was entirely composed of deciduoid areas, and only scattered tumor cells were positive for calretinin and keratin 5/6.

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