Publications by authors named "Isabelle Gagnon"
Article Synopsis
- - This study examines how symptoms from sport-related concussions (SRC) and non-SRC recover in young children aged 5 to 12 years over a period of 12 weeks.
- - The research included 1,747 children from various pediatric emergency departments and analyzed their symptom changes using a standardized inventory to gather self-reported and parent-reported data.
- - The findings aim to provide insights into the differences in symptom recovery trajectories between younger children and highlight any variations based on the type of injury experienced.
Article Synopsis
- R2Play is a new assessment tool designed for youth recovering from concussions, simulating the complex physical and cognitive challenges found in sports to ensure more effective rehabilitation.
- The study will assess the tool's feasibility, face validity, and content validity by gathering quantitative data from performance metrics and qualitative insights from interviews with clinicians and youth participants.
- Results from this study aim to refine R2Play further and set the stage for a broader multicenter study to validate its effectiveness across multiple sites.
Objective: The current study aimed to explore (1) school-aged children's auditory and cognitive abilities and (2) their perceptions (self-reported and parents) of listening behaviours and symptoms following mild traumatic brain injury (mTBI).
Design: Prospective cohort study.
Study Sample: Twenty-one children aged 8 to 12 participated in this study.
Article Synopsis
- The study highlights the significance of reducing low-value care in pediatric trauma, suggesting that it can enhance patient experiences and outcomes while minimizing unnecessary healthcare resource use.* -
- A retrospective cohort study involving over 10,700 children admitted to trauma centers in a Canadian province was conducted to identify and assess low-value practices in pediatric trauma care.* -
- The research found 19 low-value practices, with five showing moderate to high frequency and variation across hospitals, indicating a need for standardized care to improve pediatric trauma treatment.*
Article Synopsis
- This study explored the recovery trajectories of Dizziness-Related Disability (DRD) in kids aged 8-17 who experienced concussions, using evaluations over 6 months.
- Two main recovery groups were identified: a Low DRD group (79% of participants) and a High DRD group (21%).
- Key factors predicting membership in the High DRD group included chronic neck pain, existing anxiety issues, and scores from a specific assessment tool (the 5P total score), highlighting the need for personalized treatment approaches.
Background: Concussion education is recommended to increase concussion knowledge, beliefs, and reporting intentions. The Concussion Awareness Training Tool for Youth (CATT-Youth) is a 40-minute e-Learning module developed for high school-aged youth.
Aim: The aim of the study was to evaluate changes in concussion knowledge, beliefs, and reporting intentions in high school youth from Calgary, Canada, following completion of the CATT-Youth.
Background: Individuals with a moderate-to-severe traumatic brain injury (m/sTBI), despite experiencing good locomotor recovery six months post-injury, face challenges in adapting their locomotion to the environment. They also present with altered cognitive functions, which may impact dual-task walking abilities. Whether they present collision avoidance strategies with moving pedestrians that are altered under dual-task conditions, however, remains unclear.
View Article and Find Full Text PDFDespite the generally accepted role of the hydrophobic effect as the driving force for folding, many intrinsically disordered proteins (IDPs), including those with hydrophobic content typical of foldable proteins, behave nearly as self-avoiding random walks (SARWs) under physiological conditions. Here, we tested how temperature and ionic conditions influence the dimensions of the N-terminal domain of pertactin (PNt), an IDP with an amino acid composition typical of folded proteins. While PNt contracts somewhat with temperature, it nevertheless remains expanded over 10-58°C, with a Flory exponent, ν, >0.
View Article and Find Full Text PDFArticle Synopsis
- Social determinants of health (SDH) significantly influence child health outcomes, particularly regarding accessing care and the quality of care following injuries, but this relationship has not been systematically reviewed.
- The study will utilize Cochrane methodology to conduct a systematic review of various observational and experimental studies, analyzing factors such as race, socioeconomic status, and education that affect pediatric care after injuries.
- The findings aim to inform clinicians and policymakers to improve care systems and ensure equitable access to quality care for children and adolescents following traumatic events.
Importance: Research on postconcussive symptoms (PCS) following early childhood concussion has been hindered by a lack of measures suitable for this age group, resulting in a limited understanding of their evolution in young children.
Objective: To document PCS in the first 3 months after early childhood concussion using a developmentally appropriate measure.
Design, Setting, And Participants: This cohort study used data collected at 3 Canadian and 1 US urban pediatric emergency departments (EDs) and 8 Canadian daycares from December 2018 to December 2022 as part of the Kids' Outcomes and Long-Term Abilities (KOALA) project, a prospective, multicenter, longitudinal cohort study.
Study Objective: Our primary objectives were to identify clinical practice guideline recommendations for children with acute mild traumatic brain injury (mTBI) presenting to an emergency department (ED), appraise their overall quality, and synthesize the quality of evidence and the strength of included recommendations.
Methods: We searched MEDLINE, EMBASE, Cochrane Central, Web of Science, and medical association websites from January 2012 to May 2023 for clinical practice guidelines with at least 1 recommendation targeting pediatric mTBI populations presenting to the ED within 48 hours of injury for any diagnostic or therapeutic intervention in the acute phase of care (ED and inhospital). Pairs of reviewers independently assessed overall clinical practice guideline quality using the Appraisal of Guidelines Research and Evaluation (AGREE) II tool.
Article Synopsis
- - The 6th International Consensus Conference on Concussion in Sport, held in Amsterdam in 2022, focused on updated evidence and recommendations for managing sport-related concussions (SRC) in children and adolescents, emphasizing prevention strategies like mouthguard use and policy changes in sports.
- - The conference highlighted the importance of the Sport Concussion Assessment Tools (SCAT) for diagnosing concussions within the first 72 hours, and the development of comprehensive evaluation tools for longer-term assessments, known as SCOAT6 for different age groups.
- - Recommendations include early light physical activity instead of strict rest for recovery, targeted rehabilitation for persistent symptoms, and the recognition of varying impacts of SRC across diverse populations, while pointing out the limited utility of
Objective: To document (1) oculomotor (OM) and vestibulo-ocular (VO) function in children with concussion who were symptomatic at the time of assessment and to compare it with that in children with concussion who were clinically recovered (asymptomatic) and in children with no concussive injury, and (2) the extent to which OM and VO function relates to postconcussion symptom severity in injured children.
Setting: Participants were recruited from a concussion clinic or the community.
Participants: A total of 108 youth with concussion (72 symptomatic; 36 recovered) and 79 healthy youth (aged 9-18 years).
Importance: Adult trauma centers (ATCs) have been shown to decrease injury mortality and morbidity in major trauma, but a synthesis of evidence for pediatric trauma centers (PTCs) is lacking.
Objective: To assess the effectiveness of PTCs compared with ATCs, combined trauma centers (CTCs), or nondesignated hospitals in reducing mortality and morbidity among children admitted to hospitals following trauma.
Data Sources: MEDLINE, Embase, and Web of Science through March 2023.
Background: Lack of adherence to recommendations on pediatric orthopaedic injury care may be driven by lack of knowledge of clinical practice guidelines (CPGs), heterogeneity in recommendations or concerns about their quality. We aimed to identify CPGs for pediatric orthopaedic injury care, appraise their quality, and synthesize the quality of evidence and the strength of associated recommendations.
Methods: We searched Medline, Embase, Cochrane CENTRAL, Web of Science and websites of clinical organizations.
Objective: Little is known about the symptoms, signs, and management guidelines for children under the age of 6 years after they sustain a concussion. Caregivers of such young children may have unique concerns and encounter different challenges from those of school-age children given the distinctive developmental characteristics of the early childhood period. This study aimed to explore the experience of caregivers through semistructured interviews to inform clinical practice.
View Article and Find Full Text PDFThis study aimed to investigate the impact of traumatic subarachnoid hemorrhage (tSAH) on cardiac autonomic control system (CACS) function in children after severe traumatic brain injury (TBI) during the subacute rehabilitation period. Thirty-three participants, 8-18 years of age, 42 (14-149) days after severe TBI at the beginning of the subacute rehabilitation, were included in the study. Six participants were diagnosed with tSAH during acute medical care (tSAH group).
View Article and Find Full Text PDFTraumatic brain injury (TBI) is the leading cause of death and disability in children. Many clinical practice guidelines (CPGs) have addressed pediatric TBI in the last decade but significant variability in the use of these guidelines persists. Here, we systematically review CPGs recommendations for pediatric moderate-to-severe TBI, evaluate the quality of CPGs, synthesize the quality of evidence and strength of included recommendations, and identify knowledge gaps.
View Article and Find Full Text PDFObjective: To systematically review clinical practice guidelines (CPGs) for pediatric multisystem trauma, appraise their quality, synthesize the strength of recommendations and quality of evidence, and identify knowledge gaps.
Background: Traumatic injuries are the leading cause of death and disability in children, who require a specific approach to injury care. Difficulties integrating CPG recommendations may cause observed practice and outcome variation in pediatric trauma care.
Objectives: We evaluated interventions to facilitate recovery in children, adolescents and adults with a sport-related concussion (SRC).
Design: Systematic review including risk of bias (modified Scottish Intercollegiate Guidelines Network tool).
Data Sources: MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Embase, APA PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL Plus with Full Text, SPORTDiscus and Scopus searched until March 2022.
Article Synopsis
- The study aimed to evaluate which tests and measures can effectively diagnose persisting post-concussive symptoms (PPCS) in people of different ages after sport-related concussions (SRC).
- A systematic review of literature was conducted, screening 3,298 records to include 26 relevant studies with varied participant demographics and methodologies, primarily focusing on comparisons between those with PPCS and control groups.
- The findings suggest that current diagnostic methods heavily rely on self-reported symptoms, as no specific tool or measure demonstrates adequate accuracy; more robust, long-term studies are needed for improved clinical diagnosis.
Objective: To synthesise the evidence regarding the risks and benefits of physical activity (PA), prescribed aerobic exercise treatment, rest, cognitive activity and sleep during the first 14 days after sport-related concussion (SRC).
Design: Meta-analysis was performed for PA/prescribed exercise interventions and a narrative synthesis for rest, cognitive activity and sleep. Risk of bias (ROB) was determined using the Scottish Intercollegiate Guidelines Network and quality assessed using Grading of Recommendations, Assessment, Development and Evaluations.
Background: Observed variations in the management of pediatric solid organ injuries (SOIs) may be due to difficulty in finding and integrating recommendations from multiple clinical practice guidelines (CPGs) with heterogeneous methodological approaches. We aimed to systematically review CPG recommendations for pediatric SOIs.
Methods: We conducted a systematic review of CPGs including at least one recommendation targeting pediatric SOI populations, using Medical Analysis and Retrieval System Online, Excerpta Medica dataBASE, Web of Science, and websites of clinical organizations.
Graded exertion testing (GXT) is an important tool for concussion management, as it is used to personalize post-concussion exercise prescription and return athletes to sport. However, most GXT requires expensive equipment and in-person supervision. Our objective was to assess the safety and feasibility of the ntreal irtual xertion (MOVE) protocol, a no-equipment, virtually compatible GXT, in healthy children and children with subacute concussion.
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