Publications by authors named "Isabelle Chiao Han Sung"
Article Synopsis
- - Changes in mitochondrial shape are linked to how cells utilize nutrients, particularly the process of breaking down fatty acids (FAO), with increased fragmentation leading to higher FAO rates.
- - Forcing mitochondria to elongate decreases FAO, while inducing fragmentation boosts FAO across different cell types, influencing functions like gluconeogenesis and insulin secretion.
- - The study identifies that mitochondrial fragmentation affects the regulation of FAO through the enzyme CPT1, which is influenced by malonyl-CoA levels, highlighting its role in how cells prefer and use different fuel sources.
Proper embryonic development requires directional axes to pattern cells into embryonic structures. In Drosophila, spatially discrete expression of transcription factors determines the anterior to posterior organization of the early embryo, while the Toll and TGFβ signalling pathways determine the early dorsal to ventral pattern. Embryonic MAPK/ERK signaling contributes to both anterior to posterior patterning in the terminal regions and to dorsal to ventral patterning during oogenesis and embryonic stages.
View Article and Find Full Text PDFHomeostasis in adult organs involves replacement of cells from a stem cell pool maintained in specialized niches regulated by extracellular signals. This cell-to-cell communication employs signal transduction pathways allowing cells to respond with a variety of behaviors. To study these cellular behaviors, signaling must be perturbed within tissues in precise patterns, a technique recently made possible by the development of optogenetic tools.
View Article and Find Full Text PDFDevelopmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans.
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