Adapting to their new home: Eosinophils remodel the gut architecture.

In this issue of JEM, Diny et al. (2022. J.

T4SS-dependent TLR5 activation by Helicobacter pylori infection.

Toll-like receptor TLR5 recognizes a conserved domain, termed D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Highly virulent H. pylori strains possess a type IV secretion system (T4SS) for delivery of virulence factors into gastric epithelial cells.