Evaluation of -alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors.

Two series of -alkyl isatins and -alkyl indoles varying in size of the alkyl group were synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among the -alkyl isatins -, the addition of the -alkyl group improved inhibition potency towards AChE and BChE compared to isatin. Selectivity towards inhibition of BChE was observed, and the increase in size of the -alkyl group positively correlated to improved inhibition potency.