Publications by authors named "Isabella V Trachtenberg"
Article Synopsis
- Uveal melanoma often has mutations in GNAQ or GNA11, activating the MAPK signaling pathway, but there are no effective targeted treatments for this form of cancer.
- Researchers used a Gαq/11 inhibitor on GNAQ-mutant uveal melanoma cell lines and identified 22 kinases with altered expression or activity, potentially revealing new therapeutic targets.
- They found that knocking down specific kinases, MARK3 and STK10, reduced cancer cell growth and affected certain cellular processes, suggesting a significant role of these kinases in the Gαq/11 signaling pathway and their potential as targets for treatment.
Unlabelled: The transcription factor, SOX10, plays an important role in the differentiation of neural crest precursors to the melanocytic lineage. Malignant transformation of melanocytes leads to the development of melanoma, and SOX10 promotes melanoma cell proliferation and tumor formation. SOX10 expression in melanomas is heterogeneous, and loss of SOX10 causes a phenotypic switch toward an invasive, mesenchymal-like cell state and therapy resistance; hence, strategies to target SOX10-deficient cells are an active area of investigation.
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