Publications by authors named "Isabella Richter"
Article Synopsis
- Vascular endothelial cells react to changes in their environment, such as how stiff the substrate is, impacting barrier functions in conditions like atherosclerosis, but the effects on blood-brain barrier (BBB) cells are less understood.
- This study used hydrogel substrates of different stiffness to examine how induced pluripotent stem cell-derived brain microvascular endothelial-like cells (BMEC-like) behave, assessing changes through imaging and functional tests like transendothelial electrical resistance (TEER).
- Results showed that softer substrates enhance TEER longevity and alter the formation of actin stress fibers, indicating that stiffness affects passive barrier function in BBB cells, which could improve understanding of BBB issues in neurodegenerative diseases.
The crystal structures of phenylpropylpyridine-N-oxide and N-methyl-phenylpropylpyridinium iodide are compared, revealing that hydrogen bonding with the solvent molecule plays an important role in the N-oxide compound, whilst electrostatic interactions are predominant in controlling the solid-state orientation of the N-methylated compound. Fluorescence spectroscopy and NOESY indicate that in contrast to the previously reported pyridinium iodide, the N-oxide is not subject to intramolecular pi-stacking, as judged by excimer emission and a lack of corresponding cross peaks, respectively.
View Article and Find Full Text PDFNOEsy and fluorescence spectroscopy reveal that conversion of conformationally flexible (phenylalkyl)pyridines into their corresponding N-methyl-pyridinium iodides results in intramolecular pi-stacking.
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