Publications by authors named "Isabella R Posner"
Article Synopsis
- Acute kidney injury (AKI) can lead to severe lung dysfunction and contributes to high mortality rates due to multiorgan failure.
- The study investigates how molecules released from injured kidney cells, called DAMPs, trigger an inflammatory response in lung cells through pattern recognition receptors (PRRs).
- Researchers found that DAMPs cause increased cytokine production and cell permeability in lung endothelial cells, and inhibiting specific receptors (NOD1 and NOD2) may reduce this response, potentially informing future treatments for AKI-related lung injuries.
