Sodium nitroprusside in acute heart failure: A multicenter historic cohort study.

Aims: Despite evidence of hemodynamic benefit of sodium nitroprusside (SNP) treatment for acute heart failure (AHF), there are limited data about its efficacy and safety. This study aimed to assess the effectiveness and safety of SNP treatment, to explore the impact of N-terminal pro-B natriuretic peptide (NT-proBNP) reduction on clinical endpoints and to identify possible predictors of clinical response.

Methods And Results: Multicenter retrospective cohort study of 200 patients consecutively admitted for AHF in 2 Italian Centers.