Publications by authors named "Isabella L Siman"
Background: There have been no data on sublingual immunotherapy (SLIT) in Brazilian patients sensitized to house dust mites. This study aimed to evaluate the mucosal/systemic antibody response changes and clinical efficacy after SLIT using Dermatophagoides pteronyssinus (Dpt) allergens with or without bacterial extracts in mite-allergic Brazilian children.
Methods: Patients with allergic rhinitis and asthma were selected for a double-blind, placebo-controlled trial randomized to three groups: DPT (Dpt extract, n = 34), DPT+MRB (Dpt plus mixed respiratory bacterial extracts, n = 36), and Placebo (n = 32).
Allergen-specific IgG antibodies purified from mite-allergic patients sera block the IgE recognition of Dermatophagoides pteronyssinus antigens: an in vitro study.
Isabella Lima Siman Lais Martins de Aquino Leandro Hideki Ynoue Juliana Silva Miranda Ana Claudia Arantes Marquez Pajuaba
Clin Dev Immunol
February 2014
Article Synopsis
- The study focused on how specific immunotherapy (SIT) can enhance IgG levels against allergens, helping to block IgE activity, particularly in relation to the allergen Dermatophagoides pteronyssinus (Dpt).
- Researchers purified Dpt-specific IgG antibodies using a series of techniques to confirm their purity and immunoreactivity, showing strong results.
- The findings demonstrated that these purified IgG antibodies significantly reduce IgE reactivity to Dpt, suggesting that tracking IgG levels could be a valuable tool for monitoring patients undergoing SIT.