Background: Topical capsaicin has been used to treat vulvodynia but has been poorly studied for use in neuroproliferative provoked vestibulodynia (PVD); capsaicin decreases allodynia by blocking vanilloid receptors (TRPV1) on C-afferent nociceptors, but the therapy causes discomfort to the point of intolerance in some patients.
Aim: The present study evaluated tolerability and efficacy of topical capsaicin to treat neuroproliferative PVD.
Methods: Patients with neuroproliferative PVD prescribed 0.