Publications by authors named "Isabella Gyamfi-Poku"
Article Synopsis
- The study investigates how aortic valve stenosis (AS) impacts endothelial function independently of usual cardiovascular risk factors in both mice and human cohorts.
- The researchers found that AS led to systemic endothelial dysfunction characterized by increased extracellular hemoglobin (eHb), nitric oxide consumption, and mechanical stress in the aorta.
- Treatment methods, including the use of haptoglobin and transcatheter aortic valve replacement, were effective in restoring endothelial function in both experimental and clinical settings.
Article Synopsis
- - The text discusses a study on aortic valve stenosis (AS), a common heart valve disease, focusing on a newly developed mouse model that mimics human AS characteristics and allows for advanced imaging techniques to assess disease progression.
- - Researchers induced AS in mice and used high-resolution MRI to analyze changes in the heart and aorta, finding significant structural and functional alterations, such as valve thickening, turbulent blood flow, and mild heart muscle growth, while global heart function remained relatively normal.
- - The study revealed early signs of myocardial tissue remodeling and coronary flow issues before overt heart failure, identifying critical points in AS progression that could help guide future treatment strategies.
Aortic valve stenosis (AS) is the most common valve disease requiring therapeutic intervention. Even though the incidence of AS has been continuously rising and AS is associated with significant morbidity and mortality, to date, no medical treatments have been identified that can modify disease progression. This unmet medical need is likely attributed to an incomplete understanding of the molecular mechanism driving disease development.
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