Publications by authors named "Isabella Evelyn Prado de Azevedo"
Preliminary Study for New Markers of Early Tubuloglomerular Injury and Renal Inflammation in Patients with Visceral Leishmaniasis Receiving Liposomal Amphotericin B Treatment.
Gabriela Freire Bezerra Gdayllon Cavalcante Meneses Vittória Nobre Jacinto Danya Bandeira Lima Emanuel Paula Magalhães Isabella Evelyn Prado de Azevedo
Am J Trop Med Hyg
April 2022
Article Synopsis
- Visceral leishmaniasis patients treated with liposomal amphotericin B (L-AMB) may experience nephrotoxicity, prompting a study to assess renal damage through specific biomarkers.
- A prospective study with 17 patients analyzed various kidney function tests and biomarkers before and during L-AMB treatment.
- Findings indicated that while traditional kidney function metrics remained stable, specific inflammatory and urinary biomarkers increased, particularly in patients who developed acute kidney injury, highlighting the need for close monitoring during treatment.
Leprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy.
View Article and Find Full Text PDFAcute Kidney Injury (AKI) is associated with high morbidity and mortality. Ischemia and reperfusion (I/R) are events that lead to AKI through hypoxia, reactive oxygen species (ROS) production, oxidative stress and apoptosis. We aimed to evaluate the mechanism of nephroprotection mediated by Bisabolol in human tubular kidney cells after injury by I/R in vitro.
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