Publications by authors named "Isabella Batten"
Article Synopsis
- Tissue-resident natural killer (trNK) cells are found in the human lung, and this study investigates their unique metabolic functions, which may play a role in their effectiveness as immune cells.
- Researchers analyzed human bronchoalveolar lavage fluid (BALF) and peripheral blood using flow cytometry and SCENITH to compare the phenotype and metabolism of NK cells in these locations, uncovering specific markers for trNK cells.
- The study discovered that lung NK cells have a significantly higher glycolytic capacity and are more reliant on glucose than those in peripheral blood, suggesting these trNK cells are better equipped to respond to challenges in the lung environment.
Article Synopsis
- Midlife cardiovascular risk factors, like Type 2 Diabetes (T2DM) and obesity, may lead to cognitive impairment and dementia, with systemic inflammation being a potential link.
- A study assessed middle-aged individuals with and without uncomplicated T2DM, measuring their cognitive abilities and levels of certain inflammatory markers (like IL-17A) over four years.
- Results showed that higher levels of IL-17A were correlated with poorer executive function, regardless of T2DM status, suggesting this inflammatory marker may play a role in cognitive decline in midlife.
Article Synopsis
- * Low-density neutrophils (LDNs) are more prevalent in severe COVID-19, negatively affecting their ability to form extracellular traps and produce reactive oxygen species, which are crucial for fighting infections.
- * Neutrophils from severe COVID-19 patients exhibit increased presence of arginase-1 but display reduced release of this protein into the bloodstream, indicating a dysfunctional immune response that can inhibit T cell activity independently of arginase-1.
Introduction: Immunometabolism examines the links between immune cell function and metabolism. Dysregulation of immune cell metabolism is now an established feature of innate immune cell activation. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have allowed discovery of unique insights into cellular metabolomics.
View Article and Find Full Text PDFMidlife Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Alzheimer Disease (AD) in later life, with altered inflammatory responses postulated as key pathological drivers. Previous studies have demonstrated increased responsiveness to NLR family pyrin domain containing 3 (NLRP3) inflammasome agonists, both in individuals with untreated T2DM in addition to those with established AD. We hypothesised that peripheral NLRP3 inflammasome responses may be altered during the early stages of T2DM-related cognitive dysfunction.
View Article and Find Full Text PDFSerological assays capable of measuring antibody responses induced by previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been critical tools in the response to the COVID-19 pandemic. In this study, we use bead-based multiplex assays to measure IgG and IgA antibodies and IgG avidity to five SARS-CoV-2 antigens (Spike (S), receptor-binding domain (RBD), Nucleocapsid (N), S subunit 2, and Membrane-Envelope fusion (ME)). These assays were performed in several cohorts of healthcare workers and nursing home residents, who were followed for up to eleven months after SARS-CoV-2 infection or up to six months after vaccination.
View Article and Find Full Text PDFObjectives: Older nursing home residents make up the population at greatest risk of morbidity and mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. No studies have examined the determinants of long-term antibody responses post vaccination in this group.
Design: Longitudinal cohort study.
Article Synopsis
- Anti-neutrophil cytoplasmic antibody (ANCA)-Associated Vasculitis (AAV) involves inflammation of small blood vessels, but its biology is not fully understood, with some studies indicating issues in type I IFN responses.
- In this study, the researchers assessed various interferon-regulated genes and proteins in AAV patients and found no significant differences compared to healthy individuals, concluding that type I IFN responses do not significantly influence AAV pathology.
Article Synopsis
- In 2008, guidelines were established for researching autophagy, which has since gained significant interest and new technologies, necessitating regular updates to monitoring methods across various organisms.
- The new guidelines emphasize selecting appropriate techniques to evaluate autophagy while noting that no single method suits all situations; thus, a combination of methods is encouraged.
- The document highlights that key proteins involved in autophagy also impact other cellular processes, suggesting genetic studies should focus on multiple autophagy-related genes to fully understand these pathways.
Midlife Type 2 Diabetes Mellitus (T2DM) is associated with a greater risk of dementia in later life. Peripheral inflammation and its impact on cognition is proposed as one of the pathological mechanisms mediating this link. However, studies have primarily focused on older individuals with established cognitive impairment and a long duration of T2DM.
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