Publications by authors named "Isabella Barbosa Santos"

Nanoformulations containing zein nanoparticles (ZN) can promote the stability and protection of molecules with acaricidal activity. The present study sought to develop nanoformulations with ZN associated with cypermethrin (CYPE) + chlorpyrifos (CHLO) + a plant compound (citral, menthol or limonene), characterize them, and verify their efficacy against Rhipicephalus microplus ticks. Additionally, we aimed to assess its safety in nontarget nematodes found in soil at a site subjected to contamination by acaricides.

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Article Synopsis
  • The study focused on improving the delivery of acaricidal compounds through the development of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) combined with cypermethrin (cip) and chlorpyrifos (chlo), along with plant-based compounds like citral, menthol, or limonene.
  • Six formulations were created and characterized, showing effective particle sizes and high encapsulation efficiency of over 98% for all active ingredients.
  • The efficacy of these formulations was tested on tick larvae, revealing that the addition of plant compounds significantly enhanced their acaricidal action, with most formulations achieving substantial mortality rates compared to control samples.
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  • This study aimed to evaluate a targeted selective treatment (TST) method for Morada Nova lambs based on their average daily weight gain (DWG), comparing it with control and routine treatments over different seasons.
  • Results showed that TST led to better resilience against anthelmintic resistance and effectively managed lamb health without significant productivity losses.
  • Overall, TST promoted sustainability in sheep breeding by maintaining genetic diversity through refugia, which helps reduce parasite resistance development.
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Two β-globin allelic haplotypes (A and B) were identified in domestic sheep, wherein animals which are homozygous for β allele (BB haplotype) have a deletion of pre-adult β-globin and consequently are less tolerant to anemia and hypoxia. Since Haemonchus contortus infection, is associated with severe anemia, studies performed from 1960s to 1990s investigated the association between β-globin haplotype and resistance against this parasite. However, the findings were controversial, pointing out from increased resistance in animals harboring the β allele to inexistence of association.

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Morada Nova is a Brazilian hair sheep breed that is well adapted to the country's mainly tropical climate and has good potential for meat and leather production. This breed is reported to be resistant to infection, a highly desired characteristic due to the large impact of this parasite on sheep farming. Therefore, the present study aimed to characterize 287 recently weaned Morada Nova lambs and 123 ewes in relation to their resistance against .

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The present study aimed to evaluate biological parameters of Rhipicephalus microplus in the non-parasitic phase in both field and laboratory conditions. It also aimed to assess correlations between duration (in days) of these parameters and climatic variables (humidity, rainfall, and soil temperature) and to estimate the annual number of generations of R. microplus in a tropical region.

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The immune response against infections is primarily associated with the Th2 profile. However, the exact mechanisms associated with increased sheep resistance against this parasite remains poorly elucidated. The present study is aimed at evaluating mediators from the innate immune response in lambs of the Morada Nova Brazilian breed with contrasting .

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The present study aimed to evaluate the viability of Haemonchus placei parasitism in experimentally infected goats. For that, 14 75 days old kids male Saanen kids were placed in one of the four experimental groups: GI - infected with 5000 H. placei L3 (n = 4); GII - infected with 5000 H.

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Morada Nova is a Brazilian hair sheep breed that is well adapted to the country's mainly tropical climate and has good potential for meat and leather production. This breed is reported to be resistant to Haemonchus contortus infection, a highly desired characteristic due to the large impact of this parasite on sheep farming. Therefore, the present study aimed to characterize 287 recently weaned Morada Nova lambs and 123 ewes in relation to their resistance against H.

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