Effects of statins on liver cell function and inflammation in septic rats.

Background: Several studies suggest that the presence of statins may be beneficial during sepsis, but this idea is controversial. The aim of this study was to investigate the effects of long-term statin treatment in the livers of septic animals, focusing on its antioxidant, antiinflammatory, and metabolic properties.

Materials And Methods: Male Wistar rats were treated orally with simvastatin, atorvastatin, or vehicle once a d.