Publications by authors named "Isabella An"
Article Synopsis
- Sleep disturbances are common in children with autism spectrum disorder (ASD) and are linked to the severity of their symptoms, especially memory issues.* -
- In a study using a mouse model of ASD, researchers found that non-rapid eye movement sleep (NREMs) was fragmented, which correlated with increased activity in certain brain neurons during sleep.* -
- By inhibiting these neurons, the study showed that sleep could be stabilized and memory improved, highlighting the significant role of the locus coeruleus noradrenergic system in regulating both sleep and memory in ASD.*
Sleep disturbances are prevalent in children with autism spectrum disorder (ASD) and have a major impact on the quality of life. Strikingly, sleep problems are positively correlated with the severity of ASD symptoms, such as memory impairment. However, the neural mechanisms underlying sleep disturbances and cognitive deficits in ASD are largely unexplored.
View Article and Find Full Text PDFSleep disturbances are prevalent in children with autism spectrum disorder (ASD) and have a major impact on the quality of life. Strikingly, sleep problems are positively correlated with the severity of ASD symptoms, such as memory impairment. However, the neural mechanisms underlying sleep disturbances and cognitive deficits in ASD are largely unexplored.
View Article and Find Full Text PDFSleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics.
Neurobiol Sleep Circadian Rhythms
May 2023
Sleep is crucial for brain development. Sleep disturbances are prevalent in children with autism spectrum disorder (ASD). Strikingly, these sleep problems are positively correlated with the severity of ASD core symptoms such as deficits in social skills and stereotypic behavior, indicating that sleep problems and the behavioral characteristics of ASD may be related.
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